Protein Alignment Ugt37B1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 162/582 - (27%)
• Similarity: 266/582 - (45%)
• Gaps: 112/582 - (19%)

  Fly     8 LALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAE---RGHNVTVVTILKP-------P 62
            |.||:..:..|..|..::.      |..:...:::..||.|   |||.|||:|..||       |
Human    11 LLLQLFCVGCGFCGKVLVW------PCDMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKP 69

  Fly    63 SLHK-DINHILVPMEEDILQAFNSVVGGMTKTDNSNAYV----------SMFRSVRQLSETFSKM 116
            |..| ::.|    |.:|             :|:.:..:|          |.::||.:|::.|.::
Human    70 SALKFEVVH----MPQD-------------RTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEI 117

  Fly   117 GDVMK---------QPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVAL-----SNP 167
            ...:|         |.|:|.|.|   ..:|::::...:.|..| :|..|.||.|:.|     .|.
Human   118 RGTLKMMCESFIYNQTLMKKLQE---TNYDVMLIDPVIPCGDL-MAELLAVPFVLTLRISVGGNM 178

  Fly   168 PSFLGYLLGNPWEVSYVPGMSVSIKG-GKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIY 231
            ....|.|   |..:||||   |.:.| ...:.|..||.|   ||...||.|.|:..:...:.|.|
Human   179 ERSCGKL---PAPLSYVP---VPMTGLTDRMTFLERVKN---SMLSVLFHFWIQDYDYHFWEEFY 234

  Fly   232 ----GDDPTLPSYEDLHK-NISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLP------ 285
                |...||  .|.:.| .|.||  .::...|.| :|..|....:||:..| ..:.||
Human   235 SKALGRPTTL--CETVGKAEIWLI--RTYWDFEFP-QPYQPNFEFVGGLHCK-PAKALPKINFYL 293

  Fly   286 QNMEQFL-SEAPNGAILLSLGS---NLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGES 346
            |.||.|: |...:|.::.||||   |:.|:  |::.:.   :.|:::.|||:|::.........:
Human   294 QEMENFVQSSGEDGIVVFSLGSLFQNVTEE--KANIIA---SALAQIPQKVLWRYKGKKPSTLGA 353

  Fly   347 ENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGI 411
            ...||. |:||.|:|.||....||||.|..|:.||.|||.||:.:|:||||..|...|...|..:
Human   354 NTRLYD-WIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAV 417

  Fly   412 KQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQS 476
            :.:..|:..:..|:.:|.|:.:..|.......|.::.|:|:.|.:..::|:|:|:|:.||.|::|
Human   418 EINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRS 482

  Fly   477 PVVHMSYIAANNLDVYAVILGTIVALCFI-TK-LLFGLVVGKLRKNSRKAKVNQKHKLKKKQ 536
            ....:::....::||...:|..:....|: || .||..           .|.|:..|::|::
Human   483 AAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFLFSC-----------QKFNKTRKIEKRE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	GT1_Gtf-like	22..461	CDD:340817	137/489 (28%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	156/562 (28%)