DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	532	Identity:	145/532 - (27%)
Similarity:	245/532 - (46%)	Gaps:	59/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHLVIQMSMARILAERGHNVTVVTILKPPSL-HKDIN----HIL-VPMEEDILQAFNSVVGGMTK 92
            ||......:...|.::.|:|||:.....|:: |....    |:. |.||::...|....:..:..
Zfish    31 SHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKERFEYHVFKVNMEKEEADAAMRDMIHLFT 95

  Fly    93 TDNSNAYVSMFRSVRQLSETFSKMGDV-----MKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLAL 152
            .|.:..|...|...:.:|: |.:.|||     ....|:|.|   .|:.:|::.....|....| :
Zfish    96 NDTAAKYEGEFVMWKVMSK-FVEFGDVYFRGLFDVGLLKTL---RDSNYDVLFSDPMMPFSDL-M 155

  Fly   153 AHKLKVPLVVALSNPPSFLG-YLLGN-PWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRL- 214
            |.||.:|.|:::....::.. .|.|. |...||||.::::......:.|..||.|:|..:...:
Zfish   156 AQKLNIPQVISMRATFAYAAERLCGQMPAPPSYVPAVALTDHLTDRMSFMERVENMLLYIVHSIA 220

  Fly   215 FMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKE 279
            |..:........|.||.|...|:  .|.:.| :.:....::...|.| ||..|....:||:..|
Zfish   221 FPLVATFTFDGYYSEILGKPTTM--CETMGK-VDICLIRTYWDFEYP-RPFPPNFKFVGGLHCK- 280

  Fly   280 QPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNI 342
             |.: |.:.:|:|: |...:|.::.||||.:|  :|.|.....:...|.::.|||:|::.
Zfish   281 -PAKPLSKELEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYS----- 337

  Fly   343 PGESENILYSK-----WVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNAD 402
             |::...|...     |:||.|:|.||....||||.|..||.||.|||.||:.||:|||||.|..
Zfish   338 -GKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLL 401

  Fly   403 VMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIR 467
            .:...|..:...|.|:.....:..::.|::||.|..::...|.::.|:|:.|.:..:||:|:|:|
Zfish   402 HIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMR 466

  Fly   468 YHGAPHIQSPVVHMSYIAANNLDVYAVILGT--------IVALCFITKLLFGLVVGKLRKNSRKA 524
            ..||.|::.....:|:...:.|||.|.:|..        :.|.||:           .|:..||.
Zfish   467 NKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFL-----------FRRCVRKT 520

  Fly   525 KVNQKHKLKKKQ 536
            :..:|.:..||:
Zfish   521 RPERKRQKNKKE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	140/517 (27%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	130/469 (28%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	140/517 (27%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	78/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840