Protein Alignment Ugt37B1 and UGT8

DIOPT Version :10

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 151/581 - (25%)
• Similarity: 262/581 - (45%)
• Gaps: 121/581 - (20%)

  Fly    19 AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHILVPMEEDILQAF 83
            |..|.|:.:...:..||:.|..::|..|.||||: ||..:    |..:||    .|.....||.:
Human    18 AKAAKIIIVPPIMFESHMYIFKTLASALHERGHH-TVFLL----SEGRDI----APSNHYSLQRY 73

  Fly    84 NSVVGGMTKTDNSNAYV-SMFRSV----------RQLSETFSKMGDVM--KQPLVKDLYEHPDNK 135
            ..:....|    |:|:: |..|::          ..:.:.::|..|:|  ...|::.|.:   .|
Human    74 PGIFNSTT----SDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKK---EK 131

  Fly   136 FDLVMVGYFMNCYQLALAHKLKVPLVV---ALSNPPSFLGYLLGNPWEVSYVPGMSVSIKGGKPL 197
            |||::|.....| ...:||.|.|...|   .|..|..     :|.|..::|||..:..:...
Human   132 FDLLLVDPNDMC-GFVIAHLLGVKYAVFSTGLWYPAE-----VGAPAPLAYVPEFNSLLTDR--- 187

  Fly   198 GFGHRVLNLLGSMAQRLFMFIIELRNARIY--REIYGDDPTLPSYEDLHKNISLI-----FFASH 255
                  :|||    ||       ::|..:|  ..:......||.||.:.:..:|:     :...|
Human   188 ------MNLL----QR-------MKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVH 235

  Fly   256 GIS----------EGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEA-PNGAILLSLGSNLK 309
            |.|          |.| ||.:|.|:.:|||..| ....||::::::::.| .:|.:|:|.|:.:|
Human   236 GSSLWMLCTDVALEFP-RPTLPNVVYVGGILTK-PASPLPEDLQRWVNGANEHGFVLVSFGAGVK 298

  Fly   310 EDHLKSSTVQKMFNVLSKLQQKVIWKWD-----DLDNIPGESENILYSKWVPQVDVLAHPNITLF 369
              :|......|:...|.:|.|||||::.     :|.|      |....:|:||.|:|.|..|..|
Human   299 --YLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGN------NTKLIEWLPQNDLLGHSKIKAF 355

  Fly   370 ITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNP 434
            ::|.|...:.|..|||.|::.:|:|||.......:...|.||.....|:.|....:.:.:|::||
Human   356 LSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP 420

  Fly   435 KYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDV-YAVILGT 498
            .|....:..|.:::|:|..|....|||::|:||::||.|:::.|..:|:.....||: :.::||.
Human   421 SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGA 485

  Fly   499 IV---ALCFITKLLF---------------------GLVVGKLRKNSRKAKVNQKHKLKKK 535
            .:   .|.::||.::                     |::.||.::|.     :.||:.|.|
Human   486 ALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNG-----HIKHEKKVK 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	GT1_Gtf-like	22..461	CDD:340817	125/477 (26%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	142/532 (27%)