Protein Alignment Ugt37B1 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 149/520 - (28%)
• Similarity: 258/520 - (49%)
• Gaps: 53/520 - (10%)

  Fly    34 SHLVIQMSMARILAERGHNVTVVT----ILKPPSLHKDINHILVP---MEEDILQAFNSVVGGMT 91
            ||.:...::...|.:|||.|.|:|    ||...|....|...:.|   .:.|:...|..:....|
Human    34 SHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWT 98

  Fly    92 KTDNSNAYVSMFRSVRQLSETFS----KMGD--VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQL 150
            .:.:.|.:.|.|..:::|...:|    |:.:  |:.:.|::.|.|   :|||:::......|.:|
Human    99 YSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQE---SKFDVLLADAVNPCGEL 160

  Fly   151 ALAHKLKVPLVVALSNPPSFLGYLL-----GNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSM 210
             ||..|.:|.:.:|.   ..:||.:     |..:..||||.:...:  ...:.|..|:.|::..:
Human   161 -LAELLNIPFLYSLR---FSVGYTVEKNGGGFLFPPSYVPVVMSEL--SDQMIFMERIKNMIYML 219

  Fly   211 AQRLFMFIIELRN-ARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGG 274
            ....:....:|:. .:.|.|:.|...||  :|.:.| ..:....::...|.| ||.:|.|..:||
Human   220 YFDFWFQAYDLKKWDQFYSEVLGRPTTL--FETMGK-AEMWLIRTYWDFEFP-RPFLPNVDFVGG 280

  Fly   275 IQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWD 337
            :..|  |.: ||:.||:|: |...||.::.||||.:  .::...:...:.:.|:::.|||:|::|
Human   281 LHCK--PAKPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFD 341

  Fly   338 DLDNIPGESENILYS-----KWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQ 397
                  |:..|.|.|     ||:||.|:|.||....||||.|..|:.||.|||.||:.:|:|.||
Human   342 ------GKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQ 400

  Fly   398 PSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWV 462
            ..|...|...|..:...|.|:.....|..::.|:::|.|...:...|.::.|:|:.|.:..::|:
Human   401 HDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWI 465

  Fly   463 EYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF-ITK-LLFGLVVGKLRKNSRKAK 525
            |:|:|:.||.|::....::::|..::|||.|.:|..:..:.| ||| .||  ...||.|..:|.|
Human   466 EFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLF--CFRKLAKTGKKKK 528

  Fly   526  525
            Human   529  528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	GT1_Gtf-like	22..461	CDD:340817	125/452 (28%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	144/508 (28%)