Protein Alignment Ugt37B1 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 157/536 - (29%)
• Similarity: 250/536 - (46%)
• Gaps: 95/536 - (17%)

  Fly    40 MSMARILAE---RGHNVTVV----TILKPPSLHKDINHILVPMEEDILQAFNSVVGGMTKTDNSN 97
            |:|..||.|   |||.|||:    :||..|:....:...:.|.             .:|||:..|
Human    36 MNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPT-------------SLTKTEFEN 87

  Fly    98 AYVSMFRSVRQLSE--------TFSK-------MGDVMK---------QPLVKDLYEHPDNKFDL 138
            ..:.:   |::|||        .||:       :.|:::         :.|:|.|.|   ::||:
Human    88 IIMQL---VKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQE---SRFDI 146

  Fly   139 VMVGYFMNCYQLALAHKLKVPLVVALSNPP--SFLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGH 201
            |....::.|.:| ||....:|.|.:.|..|  ||..:..|..:..||||  .|..|....:.|..
Human   147 VFADAYLPCGEL-LAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYVP--VVMSKLSDQMTFME 208

  Fly   202 RVLNLLGSMAQRLFMFIIELRNAR----IYREIYGDDPTLPSYEDLHK-NISLI-----FFASHG 256
            ||.|:|..:   .|.|..::.|.:    .|.|:.|...||.  |.:.| :|.|:     |...|
Human   209 RVKNMLYVL---YFDFWFQIFNMKKWDQFYSEVLGRPTTLS--ETMRKADIWLMRNSWNFKFPH- 267

  Fly   257 ISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQ 319
                |..|||..|   ||:..|  |.: ||:.||:|: |...||.::.||||      :.|:..:
Human   268 ----PFLPNVDFV---GGLHCK--PAKPLPKEMEEFVQSSGENGVVVFSLGS------MVSNMTE 317

  Fly   320 KMFNV----LSKLQQKVIWKWDDLDNIPGE-SENILYSKWVPQVDVLAHPNITLFITHAGKGGLT 379
            :..||    |:|:.|||:|::|  .|.|.. ..|....||:||.|:|.||....||||.|..|:.
Human   318 ERANVIATALAKIPQKVLWRFD--GNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIY 380

  Fly   380 EAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFS 444
            ||.|||.||:.:|:|.|||.|...|...|..::....|:.....|..::.|:::|.|...:...|
Human   381 EAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLS 445

  Fly   445 TLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLL 509
            .:..|:|:.|.:..::|:|:|:|:.||.|::....::::...::|||...:|..:..:.||....
Human   446 RIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKC 510

  Fly   510 FGLVVGKLRKNSRKAK 525
            ......|..:..:|.|
Human   511 CLFCFWKFARKGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	155/532 (29%)
		egt	13..483	CDD:223071	148/492 (30%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	155/532 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840