Protein Alignment Ugt37B1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 155/519 - (29%)
• Similarity: 251/519 - (48%)
• Gaps: 77/519 - (14%)

  Fly    46 LAERGHNVTVV----TILKPPSLHKDINHILVPME------EDILQAFNSVVGGMTKTDNSNAYV 100
            |.:|||.|||:    :|...|:....:...:.|:.      |||::........:.|    :.:.
Human    46 LVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPK----DTFW 106

  Fly   101 SMFRSVRQLSETFSKMGDVMK---------QPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKL 156
            |.|..|:::..||:   |:::         :.|:|.|.|   ::||:|:........:| ||..|
Human   107 SYFSQVQEIMWTFN---DILRKFCKDIVSNKKLMKKLQE---SRFDVVLADAVFPFGEL-LAELL 164

  Fly   157 KVPLVVALSNPPSFL-----GYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFM 216
            |:|.|.:|...|.:.     |.||..|   ||||.:...:  ...:.|..||.|::..:....:.
Human   165 KIPFVYSLRFSPGYAIEKHSGGLLFPP---SYVPVVMSEL--SDQMTFIERVKNMIYVLYFEFWF 224

  Fly   217 FIIELRN-ARIYREIYGDDPTLPSYEDLHK-NISLI-----FFASHGISEGPIRPNVPAVIEIGG 274
            .|.:::. .:.|.|:.|...||.  |.:.| :|.||     |...|     |:.|||..|   ||
Human   225 QIFDMKKWDQFYSEVLGRPTTLS--ETMAKADIWLIRNYWDFQFPH-----PLLPNVEFV---GG 279

  Fly   275 IQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNV----LSKLQQKVI 333
            :..|  |.: ||:.||:|: |...||.::.||||      :.|:|.::..||    |:|:.|||:
Human   280 LHCK--PAKPLPKEMEEFVQSSGENGVVVFSLGS------MVSNTSEERANVIASALAKIPQKVL 336

  Fly   334 WKWDDLDNIPGE-SENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQ 397
            |::|  .|.|.. ..|....||:||.|:|.||....||||.|..|:.||.|||.||:.:|:|.||
Human   337 WRFD--GNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQ 399

  Fly   398 PSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWV 462
            |.|...|...|..:.....|:.....|..::.|:::|.|.......|.::.|:|:.|.:..::|:
Human   400 PDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWI 464

  Fly   463 EYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF-ITKLLFGLVVGKLRKNSRKAK 525
            |:|:|:.||.|::.....:::...::|||...:|..:..:.| |||.||  .|.|..:..:|.|
Human   465 EFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLF--CVWKFVRTGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	GT1_Gtf-like	22..461	CDD:340817	134/452 (30%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	153/515 (30%)