DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	535	Identity:	151/535 - (28%)
Similarity:	258/535 - (48%)	Gaps:	56/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVT-----ILKPPSL 64
            :|.....::.:::|.:|..:| :| .|..||.|....:...|..:|||||||.     .:|..|
Zfish     5 ARLCLFSLLCVLSGTYGGKVL-VF-PLDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEES- 66

  Fly    65 HKDINHILVPMEEDILQAFNSVV---------GGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVM 120
             ...:.|.:|......:.|:.::         ||....:.......:....:.:.|...:|.|.|
Zfish    67 -PFYSSITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRM 130

  Fly   121 KQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLGNPWEVSY-- 183
            .:. .|.:....|.|||:|:....:....: ||:|..:|||..:.......|:....|..:||
Zfish   131 LED-EKVMNSIQDAKFDVVLADPAVGGGPI-LAYKFNIPLVFNVRWTIQGEGHFAIAPSPLSYIP 193

  Fly   184 VPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFM-FIIELRNARIYREIYGDDPTLPSYEDLHKNI 247
            |||:.::.|    :.|..||.|:|..:..::.| .::|...|....:.:|.:.|   |..|.::.
Zfish   194 VPGVELTDK----MSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPNVT---YFSLFQDA 251

  Fly   248 SLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKE 310
            .:....:....|.| ||.:|.::.:.|.|.|  |.: ||.::|:|: |...:|.|::|||:.:.:
Zfish   252 DIWLMRNDFTFEFP-RPTMPNIVYMSGFQCK--PAKPLPNDLEKFVESSGEHGVIVMSLGTLIAQ 313

  Fly   311 DHLKSSTVQKMFNVLSKLQQKVIWKWD-----DLDNIPGESENILYSKWVPQVDVLAHPNITLFI 370
              |.......:....::|.|||||::.     .|.|      |.|..:|:||.|:|.||.|.:|:
Zfish   314 --LPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGN------NTLLVEWLPQNDLLGHPQIKVFV 370

  Fly   371 THAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPK 435
            .|.|..|:.||.|||.|:|.||:..|||.|...|...|......|.||::..||:.::|||.||.
Zfish   371 AHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPS 435

  Fly   436 YATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIV 500
            |...::..|.|:.|:||.|.:..::|:|:|:|..||||:::....||:|..:::||...::
Zfish   436 YRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTLM---- 496

  Fly   501 ALCFITKLLFGLVVG 515
                :|..:|.|::|
Zfish   497 ----VTGFVFALMIG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	150/528 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	142/493 (29%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	148/518 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840