Protein Alignment Ugt37B1 and UGT2A2

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 149/565 - (26%)
• Similarity: 251/565 - (44%)
• Gaps: 104/565 - (18%)

  Fly     8 LALQIVVLIA--------GAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVV----TILK 60
            |.|..|||..        |:|..||          .::::.     |.:|.|||||:    |:..
Human    21 LTLTEVVLSGNVLIWPTDGSHWLNI----------KIILEE-----LIQRNHNVTVLASSATLFI 70

  Fly    61 PPSLHKDINHILVPMEEDILQAFNSVVGGMTKTDNSNAYV------------------SMFRSVR 107
            ..:....:|..::|:.              .|..|.::.:                  :.::.:.
Human    71 NSNPDSPVNFEVIPVS--------------YKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELG 121

  Fly   108 QLSETFSKMG-----DVMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALS-N 166
            :|.:||.::.     .|:|.|  |.:.......||:::......|..| :|.||.:|.:..|. :
Human   122 KLLDTFFQINIQLCDGVLKNP--KLMARLQKGGFDVLVADPVTICGDL-VALKLGIPFMYTLRFS 183

  Fly   167 PPSFLGYLLGN-PWEVSYVPGMSVSIKGGKPLGFGHRVLNLLG-SMAQRLFMFIIELRNARIYRE 229
            |.|.:....|. |..|||||.....:.  ..:.||.|:.|.:. |:...:|.......|: .|.:
Human   184 PASTVERHCGKIPAPVSYVPAALSELT--DQMTFGERIKNTISYSLQDYIFQSYWGEWNS-YYSK 245

  Fly   230 IYGDDPTLPSYEDLHK-NISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL 292
            |.|...||  .|.:.| .|.||  .::...|.| ||.:|....:||:..|  |.: ||:.||:|:
Human   246 ILGRPTTL--CETMGKAEIWLI--RTYWDFEFP-RPYLPNFEFVGGLHCK--PAKPLPKEMEEFI 303

  Fly   293 -SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWD-----DLDNIPGESENILY 351
             |...||.::.||||.:|  :|.......:.:.|:::.|||:|::.     .|.|      |...
Human   304 QSSGKNGVVVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKKPATLGN------NTQL 360

  Fly   352 SKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSIL 416
            ..|:||.|:|.||....||||.|..|:.||.|||.||:.:|:|.|||.|...|...|..::.::.
Human   361 FDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLN 425

  Fly   417 TLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHM 481
            |:.....|..:|.|::.|.|.......|.::.|:|:.|.:..::|:|:|:|:.||.|::.....:
Human   426 TMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDL 490

  Fly   482 SYIAANNLDVYAVIL-------GTIVALCFITKLLFGLVVGKLRK 519
            ::...::|||...:|       ..::..|..:...|| .:||.:|
Human   491 TWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFG-KIGKKKK 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	147/561 (26%)
		egt	13..483	CDD:223071	137/515 (27%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	139/543 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840