DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37B1 and ugt8

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	565	Identity:	152/565 - (26%)
Similarity:	242/565 - (42%)	Gaps:	89/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILK----PPSLHKD 67
            |||..:      :..|.|:.:...:..|||.|..::|..|...||: ||..:.:    |||.|..
Zfish    13 CLATSL------SWAAKIVVVPPIMFESHLYIFKTLASALHAEGHD-TVFLVSEGREIPPSNHYR 70

  Fly    68 INHILVP------MEEDILQA--FNSVVGGMTK----------TDNSNAYVSMFRSVRQLSETFS 114
            :..  .|      ..:|.||:  .|...|.:|.          :.|.:|.|.....:.||..
Zfish    71 LQR--YPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQLKR--- 130

  Fly   115 KMGDVMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVV---ALSNPPSFLGYLLG 176
                           ||    |||::|.....| ...:||.|.|...|   .|..|..     :|
Zfish   131 ---------------EH----FDLLLVDPNEMC-GFVIAHILGVQYAVFSTGLWYPAE-----VG 170

  Fly   177 NPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRL-FMFIIELRNARIYREIYGDDPTLPSY 240
            .|..:||||..:..:.  ..:....||.|....:..|. ..|::..:..||.|: |...|:: |.
Zfish   171 APAPLSYVPEFNSLLT--DHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRK-YNIQPSV-SM 231

  Fly   241 EDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEA-PNGAILLSL 304
            .||.:|..|....:....|.| ||.:|.|:.:|||..| .|..|||..|.::.:. .:|.:::|.
Zfish   232 HDLVQNSRLWMLCTDMALEFP-RPTLPHVVYVGGILTK-PPSPLPQEFETWVKDTDEDGFVVVSF 294

  Fly   305 GSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGES--ENILYSKWVPQVDVLAHPNIT 367
            |:.:|  :|.....||:...||:|.|:|||::   ..:|..:  .|.....|:||.|:|...|..
Zfish   295 GAGVK--YLSDDIAQKLAGALSRLPQRVIWRF---SGVPPSNLGNNTKLVDWMPQNDLLGQTNTR 354

  Fly   368 LFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLD 432
            .|::|.|...:.||.|||.|::.:|:|||.......:...|.||......:.|:.....:..|:.
Zfish   355 AFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVIT 419

  Fly   433 NPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILG 497
            :.:|....:..|.:::|:|..|....:||:.|::|:.||.|::|.|..:.......||| |:::|
Zfish   420 DKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDV-AMVIG 483

  Fly   498 TIVAL---CF--ITKLL-FGLVVG-----KLRKNSRKAKVNQKHK 531
            ..:.|   |.  |.|.: |.|..|     |:..:......|.|||
Zfish   484 VCLLLTGYCLYRIVKFIQFRLGRGSSPGEKVNGHCHNGIPNGKHK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	145/550 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	132/498 (27%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	141/520 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840