Protein Alignment Ugt37B1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 152/569 - (26%)
• Similarity: 256/569 - (44%)
• Gaps: 89/569 - (15%)

  Fly     3 GISRCLALQ--------IVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAE---RGHNVTVV 56
            |:...|::|        :||.|.|:|                  .:||..:|.|   |||...|:
Human    15 GLLLLLSVQPWAESGKVLVVPIDGSH------------------WLSMREVLRELHARGHQAVVL 61

  Fly    57 TILKPPSLHKDINHILVPMEEDIL-----------QAFNSVVGGMTKT--DNSNAYVSMFRSVRQ 108
            |    |.::..|.      ||:..           ..|:..|.|.|:.  :..:.....|||:..
Human    62 T----PEVNMHIK------EENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAM 116

  Fly   109 LSETFSKMGDVMKQPLVKDLYEHP------DNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNP 167
            |    :.|..|..:..|:.|:...      ...||:|:... :|.....||..|.:|.|..|.|.
Human   117 L----NNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDP-VNLCAAVLAKYLSIPTVFFLRNI 176

  Fly   168 P---SFLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYRE 229
            |   .|.|....||  .||:|.:..:  ....:.|..||.|:|..:|............|.:..|
Human   177 PCDLDFKGTQCPNP--SSYIPRLLTT--NSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASE 237

  Fly   230 IYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-S 293
            ::..:   .|..|:..:.|:..|....:.:.| ||.:|.::.||||....: :.|.|..|.:: :
Human   238 LFQRE---VSVVDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYINA 297

  Fly   294 EAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVP 356
            ...:|.::.||||.:.|  :.......:.:.|.|:.|.|:|::...  .|:   :.|.:..||:|
Human   298 SGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLP 357

  Fly   357 QVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEED 421
            |.|:|.||....||||||..|:.|:..:|.||:.:|:||||..||..|...|.|:..::|.:..:
Human   358 QNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE 422

  Fly   422 SFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIA 485
            .....::.|:::..|...:...|:|::|||:.|.:..::|||:|:|:.||||:: |..| :::..
Human   423 DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQ 486

  Fly   486 ANNLDVYAVILGTIVALCFITKLLFGLVVGKLRK-NSRKAKVNQKHKLK 533
            .::|||...:|..::.:.|||   |.......|| ..:|.:|.:.||.|
Human   487 YHSLDVIGFLLAVVLTVAFIT---FKCCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	144/540 (27%)
		egt	13..483	CDD:223071	134/498 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	145/546 (27%)
		egt	<262..508	CDD:223071	80/256 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840