Protein Alignment Ugt37B1 and UGT1A1

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 153/563 - (27%)
• Similarity: 274/563 - (48%)
• Gaps: 69/563 - (12%)

  Fly     2 GGISRCLALQIVVLIAG---AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKP-P 62
            ||  |.|.|.:::.:.|   :|...|  |...:..||.:..:...:.|.:|||.:.|   |.| .
Human     7 GG--RPLVLGLLLCVLGPVVSHAGKI--LLIPVDGSHWLSMLGAIQQLQQRGHEIVV---LAPDA 64

  Fly    63 SLH-KD-----INHILVPME-EDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGD-- 118
            ||: :|     :....||.: ||:.::|.|:  |....:|.:....:.::.:::.:..:.:..
Human    65 SLYIRDGAFYTLKTYPVPFQREDVKESFVSL--GHNVFENDSFLQRVIKTYKKIKKDSAMLLSGC 127

  Fly   119 ---VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGY---LLGN 177
               :..:.|:..|.|   :.||:::...|:.|..: :|..|.:|.|..|...|..|.:   ...|
Human   128 SHLLHNKELMASLAE---SSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPCSLEFEATQCPN 188

  Fly   178 PWEVSYVPGMSVSIKGGKPLG-------FGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDP 235
            |:  ||||         :||.       |..||.|:|.:.:|.....::....|.:..|....:.
Human   189 PF--SYVP---------RPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREV 242

  Fly   236 TLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGA 299
            |:   :||..:.|:..|.|..:.:.| ||.:|.::.:|||....| ..|.|..|.:: :...:|.
Human   243 TV---QDLLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGINCLHQ-NPLSQEFEAYINASGEHGI 302

  Fly   300 ILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDVLA 362
            ::.||||.:.|  :.......:.:.|.|:.|.|:|::...  .|:   :.|.:..||:||.|:|.
Human   303 VVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLG 362

  Fly   363 HPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGI 427
            ||....||||||..|:.|:..:|.||:.:|:||||..||..|...|.|:..::|.:..:.....:
Human   363 HPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL 427

  Fly   428 REVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDV 491
            :.|:::..|...:...|:|::|||:.|.:..::|||:|:|:.||||:: |..| :::...::|||
Human   428 KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDV 491

  Fly   492 YAVILGTIVALCFITKLLFGLVVGKLRK-NSRKAKVNQKHKLK 533
            ...:|..::.:.|||   |.......|| ..:|.:|.:.||.|
Human   492 IGFLLAVVLTVAFIT---FKCCAYGYRKCLGKKGRVKKAHKSK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	143/541 (26%)
		egt	13..483	CDD:223071	133/499 (27%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	142/531 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840