Protein Alignment Ugt37B1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 151/565 - (26%)
• Similarity: 258/565 - (45%)
• Gaps: 83/565 - (14%)

  Fly     8 LALQIVVLIA---GAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDIN 69
            ||..:::|::   .|....:|.:.|  ..||.:......|.|..|||.|.|:|:        ::|
Human    12 LATGLLLLLSVQPWAESGKVLVVPT--DGSHWLSMREALRDLHARGHQVVVLTL--------EVN 66

  Fly    70 HILVPMEEDIL-----------QAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVM--- 120
            ..:  .||:..           ..|:.::.|.|::         |.....|...||:...:|
Human    67 MYI--KEENFFTLTTYAISWTQDEFDRLLLGHTQS---------FFETEHLLMKFSRRMAIMNNM 120

  Fly   121 -------------KQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPP---S 169
                         .:.|::.|:.   ..||:|:...|..| ...||..|.:|.|..|.|.|   .
Human   121 SLIIHRSCVELLHNEALIRHLHA---TSFDVVLTDPFHLC-AAVLAKYLSIPAVFFLRNIPCDLD 181

  Fly   170 FLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDD 234
            |.|....||  .||:|.:..:  ....:.|..||.|:|..:|.......:....|.:..|::..:
Human   182 FKGTQCPNP--SSYIPRLLTT--NSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQRE 242

  Fly   235 PTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQ-VKEQPERLPQNMEQFL-SEAPN 297
               .|..||..:.|:..|....:.:.| ||.:|.::.||||. ...:|  |.|..|.:: :...:
Human   243 ---VSVVDLVSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANGKP--LSQEFEAYINASGEH 301

  Fly   298 GAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDV 360
            |.::.||||.:.|  :.......:.:.|.|:.|.|:|::...  .|:   :.|.:..||:||.|:
Human   302 GIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDL 361

  Fly   361 LAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQ 425
            |.||....||||||..|:.|:..:|.||:.:|:||||..||..|...|.|:..::|.:..:....
Human   362 LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLEN 426

  Fly   426 GIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNL 489
            .::.|:::..|...:...|:|::|||:.|.:..::|||:|:|:.||||:: |..| :::...::|
Human   427 ALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSL 490

  Fly   490 DVYAVILGTIVALCFITKLLFGLVVGKLRK-NSRKAKVNQKHKLK 533
            ||...:|..::.:.|||   |.......|| ..:|.:|.:.||.|
Human   491 DVIGFLLAVVLTVAFIT---FKCCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	144/549 (26%)
		egt	13..483	CDD:223071	134/507 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	143/539 (27%)
		egt	<262..508	CDD:223071	81/257 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840