Protein Alignment Ugt37B1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 141/538 - (26%)
• Similarity: 254/538 - (47%)
• Gaps: 82/538 - (15%)

  Fly    34 SHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHIL------------VPMEEDIL----QA 82
            ||.:....:..:|::|||.:.||.        .::|.:|            ||.:::.|    |:
Human    37 SHWLSMKDIVEVLSDRGHEIVVVV--------PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQS 93

  Fly    83 FNS--------VVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKD---LYEHPDNKF 136
            |.:        :....|:..|:...:.::              .:..|.|::|   |....::||
Human    94 FGNNHFAERSFLTAPQTEYRNNMIVIGLY--------------FINCQSLLQDRDTLNFFKESKF 144

  Fly   137 DLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLG-NPWEVSYVPGMSVSIKGGKPLGFG 200
            |.:.....:.| .:.||..|.:|.|......|..|.:... :|..|||:|  ....|....:.|.
Human   145 DALFTDPALPC-GVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIP--RCYTKFSDHMTFS 206

  Fly   201 HRVLNLLGSMAQRLFMFII-----ELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEG 260
            .||.|.|.::.:....:.:     ||.:|.:.|::  |..|      |::.:|:.......:.|.
Human   207 QRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDV--DIIT------LYQKVSVWLLRYDFVLEY 263

  Fly   261 PIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNV 324
            | ||.:|.::.||||..|::.: |.|..|.:: :...:|.::.||||.:.|  :.......:.:.
Human   264 P-RPVMPNMVFIGGINCKKRKD-LSQEFEAYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADA 324

  Fly   325 LSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKP 387
            |.|:.|.|:|::...  .|:   :.|.:..||:||.|:|.||....||||||..|:.|:..:|.|
Human   325 LGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVP 386

  Fly   388 MLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPL 452
            |:.:|:||||..||..|...|.|:..::|.:..:.....::.|:::..|...:...|:|::|||:
Human   387 MVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPV 451

  Fly   453 SPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGK 516
            .|.:..::|||:|:|:.||||:: |..| :::...::|||...:|..::.:.|||   |......
Human   452 EPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT---FKCCAYG 512

  Fly   517 LRK-NSRKAKVNQKHKLK 533
            .|| ..:|.:|.:.||.|
Human   513 YRKCLGKKGRVKKAHKSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	136/526 (26%)
		egt	13..483	CDD:223071	126/485 (26%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	133/512 (26%)
		UDPGT	27..523	CDD:278624	137/529 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840