Protein Alignment Ugt37B1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 155/551 - (28%)
• Similarity: 253/551 - (45%)
• Gaps: 53/551 - (9%)

  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDI 68
            |..|::|   :|..|...|..| |...:..||.....|:...|..|||.|.||.......|.|.:
Human    10 IPLCVSL---LLTCGFAEAGKL-LVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSL 70

  Fly    69 NHILVPME-----EDILQAFNSVVGGMTKT----------DNSNAYVSMFRSVRQLSETFSKMGD 118
            |..:....     ||:.:.|........|.          .:||.:.::|     .|...|...|
Human    71 NCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF-----FSHCRSLFND 130

  Fly   119 VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVV-ALSNPPSFLGYLLGNPWEVS 182
               :.||:.|.|   :.||.|.:..|..| .|.:|....:|.|| |......:|......|..:|
Human   131 ---RKLVEYLKE---SSFDAVFLDPFDAC-GLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLS 188

  Fly   183 YVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNI 247
            |||.:.:.....  :.|..||.|.:..:.:.||..........|..||.....|  :| ||:.:.
Human   189 YVPRILLGFSDA--MTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT--AY-DLYSHT 248

  Fly   248 SLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLKED 311
            |:....:..:.:.| :|.:|.:|.||||.. .|.:.||...|.:: :...:|.::.||||.:.|
Human   249 SIWLLRTDFVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMVSE- 310

  Fly   312 HLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDVLAHPNITLFITHAG 374
             :.......:.:.|.|:.|.|:|::...  .|:   :.|.:..||:||.|:|.||....||||||
Human   311 -IPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAG 371

  Fly   375 KGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATA 439
            ..|:.|:..:|.||:.:|:||||..||..|...|.|:..::|.:..:.....::.|:::..|...
Human   372 SHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKEN 436

  Fly   440 VKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDVYAVILGTIVALC 503
            :...|:|::|||:.|.:..::|||:|:|:.||||:: |..| :::...::|||...:|..::.:.
Human   437 IMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVA 500

  Fly   504 FITKLLFGLVVGKLRK-NSRKAKVNQKHKLK 533
            |||   |.......|| ..:|.:|.:.||.|
Human   501 FIT---FKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	147/531 (28%)
		egt	13..483	CDD:223071	137/489 (28%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	145/523 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840