Protein Alignment Ugt37B1 and UGT1A10

DIOPT Version :9

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 155/551 - (28%)
• Similarity: 252/551 - (45%)
• Gaps: 59/551 - (10%)

  Fly     7 CLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHI 71
            |:.|   :|..|...|..| |...:..||.....|:...|..|||.|.||.......|.:.:|..
Human    13 CVCL---LLTCGFAEAGKL-LVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCT 73

  Fly    72 LVPME-----EDILQAFNSVVGGMTKT----------DNSNAYVSMFRSVRQLSETFSKMGDVMK 121
            :....     ||..:.|........|.          .:|:.::.:|     .|...|...|
Human    74 VKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF-----FSHCRSLFND--- 130

  Fly   122 QPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLGN---PWEVSY 183
            :.||:.|.|   :.||.|.:..|..| .|.:|....:|.||....  .|..:|...   |..:||
Human   131 RKLVEYLKE---SSFDAVFLDPFDTC-GLIVAKYFSLPSVVFTRG--IFCHHLEEGAQCPAPLSY 189

  Fly   184 VPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNA-RIYREIYGDDPTLPSYEDLHKNI 247
            ||...:.....  :.|..||.|.:..:...||...: .||| .|..||.....|  :| ||:.:.
Human   190 VPNDLLGFSDA--MTFKERVWNHIVHLEDHLFCQYL-FRNALEIASEILQTPVT--AY-DLYSHT 248

  Fly   248 SLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLKED 311
            |:....:..:.:.| :|.:|.:|.||||.. .|.:.||...|.:: :...:|.::.||||.:.|
Human   249 SIWLLRTDFVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMVSE- 310

  Fly   312 HLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDVLAHPNITLFITHAG 374
             :.......:.:.|.|:.|.|:|::...  .|:   :.|.:..||:||.|:|.||....||||||
Human   311 -IPEKKAMAIADALGKIPQTVLWRYTGTRPSNL---ANNTILVKWLPQNDLLGHPMTRAFITHAG 371

  Fly   375 KGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATA 439
            ..|:.|:..:|.||:.:|:||||..||..|...|.|:..::|.:..:.....::.|:::..|...
Human   372 SHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKEN 436

  Fly   440 VKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDVYAVILGTIVALC 503
            :...|:|::|||:.|.:..::|||:|:|:.||||:: |..| :::...::|||...:|..::.:.
Human   437 IMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVA 500

  Fly   504 FITKLLFGLVVGKLRK-NSRKAKVNQKHKLK 533
            |||   |.......|| ..:|.:|.:.||.|
Human   501 FIT---FKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	148/534 (28%)
		egt	13..483	CDD:223071	138/492 (28%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	146/526 (28%)
		egt	<258..504	CDD:223071	81/256 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840