DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	250/532 - (46%)
Similarity:	365/532 - (68%)	Gaps:	22/532 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHILVP 74
            |.::.::|...||||||||:|.|||||:|.||:|:.|.:.|||||||::|||...||||:.|:||
  Fly     9 LLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIVVP 73

  Fly    75 MEED---ILQAFNSVVGGMTKTDNSNAYVS-MFRSVRQLSETFSKMGDVMKQPLVKDLYEHPDNK 135
            |:|:   |::...:.:.|     ..|:.|| |:|.:..:....:...:::..|..:.:||   .|
  Fly    74 MKEEQERIMEDQMTEMAG-----QKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIYE---TK 130

  Fly   136 FDLVMVGYFMNCYQLALAHKLKVPLVVA-LSNPPSFLGYLLGNPWEVSYVPGMSVSIKGGKPLGF 199
            |||:::|||:|.:||.:|||||||:::. :|.|...:....|||.|:||||.|..  ...:|:||
  Fly   131 FDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGT--VATQPMGF 193

  Fly   200 GHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRP 264
            ..|..|.|.|:.......:.:.:..|||.::: .:..:|:.::|.||||:.|..||.||||||||
  Fly   194 LKRTENALKSLLFEFIFVVFDYKLTRIYNDVF-PEQDMPTLKELRKNISMAFVGSHLISEGPIRP 257

  Fly   265 NVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQ 329
            .|||:|||||||||::|:.||::::||:|.|..||:.||||||:|...::...||.:|.|||:|:
  Fly   258 LVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELK 322

  Fly   330 QKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVF 394
            :.|||||:||:|.||.|.||||..|:||.|:|||||..||||||||||:|||||||.||:|||:|
  Fly   323 ENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIF 387

  Fly   395 GDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLI 459
            ||||.||.:|...|:|:...:|::.|||....::|||:|.||..|:..|||||||||::.:::::
  Fly   388 GDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVV 452

  Fly   460 YWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGKLRKNSRKA 524
            :|.||::|:.|||::|||.|||::|..||||:||:|:..:|....:|:|:..:|..|.   ..||
  Fly   453 FWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNKF---GGKA 514

  Fly   525 KVNQKHKLKKKQ 536
            |::|   .||||
  Fly   515 KISQ---TKKKQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	241/515 (47%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	228/474 (48%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	223/468 (48%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	230/495 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445664
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900