DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt37E1

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	229/533 - (42%)
Similarity:	337/533 - (63%)	Gaps:	13/533 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPP-SLHKDINHI 71
            :|..:..:...:.||||||:|.:.||||:::.|::.:.||:||||:||||.:||. :.|::|..|
  Fly    11 IAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVI 75

  Fly    72 LVPMEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKDLYEHPDNKF 136
            :.|..|: .|.:..........:..:.:.:|.:::.|.|.......:.|..|.||::||:|..||
  Fly    76 IAPPTEE-RQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPKIKF 139

  Fly   137 DLVMVGYFMNCYQLALAHKLKVPLVVA-LSNPPSFLGYLLGNPWEVSYVPGMSVSIKGG-KPLGF 199
            |||.:|...|.|||.:|.|||.|:::: :..|..|:..::||..:.||||.::|::..| |.:.|
  Fly   140 DLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNVNDPSYVPTVNVALNAGQKTMDF 204

  Fly   200 GHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRP 264
            |.|.:|........:|..:::.:..:.|...:.::...|:|.::.:.:||:|:..|..|||||||
  Fly   205 GLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRP 269

  Fly   265 NVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQ 329
            .||..|||||||||||.:.||:.:.:||.:|..|||..|||:|:..:..:..||..::.|||||.
  Fly   270 TVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLP 334

  Fly   330 QKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVF 394
            |:|||||:||.|.||.:.||.:..|:||.|:|||||..||||||||||:.||||||.||:|||:|
  Fly   335 QRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIF 399

  Fly   395 GDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLI 459
            |||..||::|...|||....|||:.|....|.|||||.||.|...:..||||||||||:.|:::|
  Fly   400 GDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVI 464

  Fly   460 YWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGT----IVALCFITKLLFGLVVGKLRKN 520
            ||.|||:|:.||.|:|||::|..::|.||||||.|:|..    ||.:.|:.:.:..:.:|  ..:
  Fly   465 YWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIG--YGS 527

  Fly   521 SRKAKVNQKHKLK 533
            .|||..|   |||
  Fly   528 QRKAVAN---KLK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	221/517 (43%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	208/472 (44%)
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	202/464 (44%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	180/421 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445666
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	10.000