DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	169/550 - (30%)
Similarity:	272/550 - (49%)	Gaps:	58/550 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALQIVVLIAG-----AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVT--ILKPPSLH 65
            |.|:::||:..     ..||.|||:|...|.||....:...:.||..||.:|.|:  .||.|.
  Fly     6 LVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPV-- 68

  Fly    66 KDINHILVPMEEDILQAFNSVVGGMTK---TDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKD 127
            .:|:.|.||   ::......:||.:|.   |.|...|::.:        |...:..|::...|:.
  Fly    69 ANIHDIPVP---ELFDNIEEIVGNLTNRKGTWNEFEYINQY--------TLGLVEKVLENDGVRR 122

  Fly   128 LYEHPDN-KFDLVMVGYFMNCYQLALAHKLKVPLV-VALSNPPSFLGYLLGNPWEVSYVPGMS-- 188
            ....|:: :|||::|..:.......||.....|:: :|.......:..|:||...::|:...|
  Fly   123 EILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFN 187

  Fly   189 ---VSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLI 250
               :...||:   .||.|..   |||...:.:..|.|:..:||:.:.......|..::.:|.:||
  Fly   188 WFDLDTYGGR---LGHFVDQ---SMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALI 246

  Fly   251 FFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEA-PNGAILLSLGSNLKEDHLK 314
            ....| .:..|.||.||.:||:||:.|.:||:.|||::|.|:..| .:|.|..|||:|::..:|.
  Fly   247 LVNQH-FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLS 310

  Fly   315 SSTVQKMFNVLSKLQQKVIWKW--DDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGG 377
            ....:.:.:..:.|.|:::||:  |:|.::|   .|:|.|.|.||.|:|||||:.|||||.|...
  Fly   311 KDRRKILIDTFASLPQRILWKFDADELSDVP---SNVLISPWFPQQDILAHPNVKLFITHGGLQS 372

  Fly   378 LTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKS 442
            ..|..:.|.|||.||.|.||..|.:.:...|.|:..:...:..|.|...|.::|....:....|.
  Fly   373 TVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKR 437

  Fly   443 FSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGT--------- 498
            .:..|||:|::|.:|.|:|..||:|:.||||::....::.:|..::|||    |||
  Fly   438 TADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDV----LGTFLLAVWAIL 498

  Fly   499 -IVALCFITKLLFGLVVGKLRKNSRKAKVN 527
             ||.||.| |||..::..|....|.|.|:|
  Fly   499 SIVVLCAI-KLLRAILKSKKGNISPKQKIN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	164/540 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	147/489 (30%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	146/480 (30%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	128/436 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445805
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950