DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	164/563 - (29%)
Similarity:	269/563 - (47%)	Gaps:	58/563 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGISRCLALQIVV-----LIA-----GAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTV 55
            ||||.....|.|::     |.|     |...:.||.:|.....|..:......:.||.|||||||
  Fly     1 MGGIFSVTGLGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTV 65

  Fly    56 VTILKPPSLHKDINHILVPMEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVM 120
            :..........:...|......:|:.||.:  ...|:|.:....::|......|..|     .::
  Fly    66 INTFGSDKNEPNFRVIGAKKIHEIMAAFGN--ADYTQTASQWQMLTMTTQFLNLLTT-----SIL 123

  Fly   121 KQPLVKDLYEHPDNKFDLVMVGYFMNCYQL-----ALAHKLKVPLVVALSNPPSFLGYLLGNPWE 180
            ....||||. :...|||||:    |...|.     .:.|.....:.::.....:.:..|:||...
  Fly   124 DDAAVKDLL-NSGEKFDLVI----MEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISP 183

  Fly   181 VSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNAR-IYREIYGDDPTL-PSYEDL 243
            :||.|.:..|  ..:.:.|..||:|:..:....|...|:.|.:.| :|.:.:   ||. .|.:::
  Fly   184 LSYNPLLLSS--RTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF---PTARKSLDEV 243

  Fly   244 HKNISLIFFASHGISEGPIRPNVPAVIEIGG--IQVKEQPERLPQNMEQFLSEAPNGAILLSLGS 306
            ..:.:|:....|.....| ||.:|.:||:||  :|.|.:.:.|.:.:.:|:.::..|.|..|:||
  Fly   244 LDSFALMLLGQHFSLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGS 307

  Fly   307 NLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFIT 371
            |:|...|..||.:.:....:.:.|:|:||::| |.:|.:.:|:..|||.||.|:|||||:.||||
  Fly   308 NIKSKDLPPSTRKMLMQTFASVPQRVLWKFED-DQLPEKPDNVFISKWFPQPDILAHPNVKLFIT 371

  Fly   372 HAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKY 436
            |.|.....|:.|.|||:|.||:|.||..|.......|:|:...|.::........|:|:|.||.|
  Fly   372 HGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSY 436

  Fly   437 ATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVA 501
            |.|.::.|.|:||:..:..|..|:|.|||:|:.||.|::.....:.:|..:.||.:    |.::|
  Fly   437 AAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTW----GLLIA 497

  Fly   502 LCFITKLL-----------FGLVVGKLRKNSRKAKVNQKHKLK 533
            :.|::.|:           |..::.|:|||..:|.     |||
  Fly   498 ITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEAS-----KLK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	155/540 (29%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	142/488 (29%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	141/473 (30%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	144/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445794
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950