DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	151/561 - (26%)
Similarity:	258/561 - (45%)	Gaps:	86/561 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTV----VTI-LKP-------- 61
            |.::..:..|.|..:| :| .:..||.:....:.|.|..|||...|    ||: :|.
  Rat    14 LLLLCALPWAEGGKVL-VF-PMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQT 76

  Fly    62 ---PSLHKDINHILVPMEEDILQ---AFNSVVGGMTKTDN-SNAYVSMFRSVRQLSETFSKMGDV 119
               |...::..|.|:...::..:   :...|:..|...:| |..||   ||.|         |.:
  Rat    77 YPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQRMAAVNNVSTFYV---RSCR---------GLL 129

  Fly   120 MKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLGN-PWEVSY 183
            ....|::.|   ..:.||:|:...|..| ...||..|:||.|..|.:....|.:...| |...||
  Rat   130 HNTALIQSL---NSSSFDVVLTDPFFPC-GAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSY 190

  Fly   184 VPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNIS 248
            :|.:..  .....:.|..||.|:|..:.   :|::..:.        ||....|.| :.|.:.:|
  Rat   191 IPRLLT--LNSDHMSFLDRVKNMLYPVP---WMYLCHVN--------YGSLARLAS-DLLQREVS 241

  Fly   249 LIFFASHG---------ISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLS 303
            ::....|.         :...| ||.:|.::.||||....: :.|.|..|.:: :...:|.::.|
  Rat   242 VVEILRHASVWLLRKDFVFYYP-RPFMPNMVFIGGINCANR-KPLSQEFEAYVNASGEHGIVVFS 304

  Fly   304 LGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDVLAHPNI 366
            |||.:.|  :......::...|.::.|.|:|::...  .|:   ::|.:..||:||.|:|.||..
  Rat   305 LGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL---AKNTILVKWLPQNDLLGHPKA 364

  Fly   367 TLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVL 431
            ..||||:|..|:.|...:|.||:.:|:||||..||..|...|.|:..::|.:..|.....::.|:
  Rat   365 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 429

  Fly   432 DNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDVYAVI 495
            :|..|...:...|:|::|||:.|.:..::|||||:|:.||||:: |..| :::...::|||...:
  Rat   430 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFL 493

  Fly   496 LGTIVALCFIT--------KLLFGLVVGKLR-KNSRKAKVN 527
            |..::.:.||.        :..||   ||.| |.|.|:|.:
  Rat   494 LAIVLTVVFIVYKSCAYGCRKCFG---GKGRVKKSHKSKTH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	148/553 (27%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	135/503 (27%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	143/538 (27%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	85/285 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910