Protein Alignment Ugt37B1 and Ugt1a2

DIOPT Version :10

• Sequence 1: NP_525008.2
• Gene: Ugt37B1 / 53584
• FlyBaseID: FBgn0026755
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_958826.1
• Gene: Ugt1a2 / 396527
• RGDID: 1549741
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 582
• Identity: 156/582 - (26%)
• Similarity: 258/582 - (44%)
• Gaps: 116/582 - (19%)

  Fly     3 GISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKD 67
            |:|..|.|  :..:..|.|..:| :| .:..||.:....:.|.|..|||...|   |.|
  Rat    11 GLSGLLLL--LCALPWAEGGKVL-VF-PMEGSHWLSMRDVVRELHARGHQAVV---LAP------ 62

  Fly    68 INHILVPME-EDI--LQAF----------NSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDV 119
              .:.|.|: ||.  ||.:          ..::|...|......:|..|         |..|..:
  Rat    63 --EVTVHMKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEPQHFVKTF---------FETMASI 116

  Fly   120 MKQPLVKDLYEHP---------------DNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPS 169
            .|   ..|||.:.               .:.||:|:......|..| ||..|::|.|..|.:.|.
  Rat   117 KK---FFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGAL-LAKYLQIPAVFFLRSVPC 177

  Fly   170 FLGYLLGN-PWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGD 233
            .:.|.... |...||:|.:...:  ...:.|..||.|:|..:..:   :|..|
  Rat   178 GIDYEATQCPKPSSYIPNLLTML--SDHMTFLQRVKNMLYPLTLK---YICHL------------ 225

  Fly   234 DPTLPSYED-----LHKNISLIFFASHG---------ISEGPIRPNVPAVIEIGGIQ-VKEQPER 283
              ::..||.     |.:.:||:...||.         :.:.| ||.:|.::.||||. |.::|
  Rat   226 --SITPYESLASELLQREMSLVEVLSHASVWLFRGDFVFDYP-RPIMPNMVFIGGINCVIKKP-- 285

  Fly   284 LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGE 345
            |.|..|.:: :...:|.::.||||.:.|  :......::...|.::.|.|:|::...  .|:
  Rat   286 LSQEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL--- 345

  Fly   346 SENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFG 410
            ::|.:..||:||.|:|.||....||||:|..|:.|...:|.||:.:|:||||..||..|...|.|
  Rat   346 AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAG 410

  Fly   411 IKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQ 475
            :..::|.:..|.....::.|::|..|...:...|:|::|||:.|.:..::|||||:|:.||||::
  Rat   411 VTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR 475

  Fly   476 SPVVH-MSYIAANNLDVYAVILGTIVALCFIT--------KLLFGLVVGKLR-KNSRKAKVN 527
             |..| :::...::|||...:|..::.:.||.        :..||   ||.| |.|.|:|.:
  Rat   476 -PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFG---GKGRVKKSHKSKTH 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	GT1_Gtf-like	22..461	CDD:340817	123/485 (25%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	145/552 (26%)