DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	156/582 - (26%)
Similarity:	258/582 - (44%)	Gaps:	116/582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKD 67
            |:|..|.|  :..:..|.|..:| :| .:..||.:....:.|.|..|||...|   |.|
  Rat    11 GLSGLLLL--LCALPWAEGGKVL-VF-PMEGSHWLSMRDVVRELHARGHQAVV---LAP------ 62

  Fly    68 INHILVPME-EDI--LQAF----------NSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDV 119
              .:.|.|: ||.  ||.:          ..::|...|......:|..|         |..|..:
  Rat    63 --EVTVHMKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEPQHFVKTF---------FETMASI 116

  Fly   120 MKQPLVKDLYEHP---------------DNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPS 169
            .|   ..|||.:.               .:.||:|:......|..| ||..|::|.|..|.:.|.
  Rat   117 KK---FFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGAL-LAKYLQIPAVFFLRSVPC 177

  Fly   170 FLGYLLGN-PWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGD 233
            .:.|.... |...||:|.:...:  ...:.|..||.|:|..:..:   :|..|
  Rat   178 GIDYEATQCPKPSSYIPNLLTML--SDHMTFLQRVKNMLYPLTLK---YICHL------------ 225

  Fly   234 DPTLPSYED-----LHKNISLIFFASHG---------ISEGPIRPNVPAVIEIGGIQ-VKEQPER 283
              ::..||.     |.:.:||:...||.         :.:.| ||.:|.::.||||. |.::|
  Rat   226 --SITPYESLASELLQREMSLVEVLSHASVWLFRGDFVFDYP-RPIMPNMVFIGGINCVIKKP-- 285

  Fly   284 LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGE 345
            |.|..|.:: :...:|.::.||||.:.|  :......::...|.::.|.|:|::...  .|:
  Rat   286 LSQEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL--- 345

  Fly   346 SENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFG 410
            ::|.:..||:||.|:|.||....||||:|..|:.|...:|.||:.:|:||||..||..|...|.|
  Rat   346 AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAG 410

  Fly   411 IKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQ 475
            :..::|.:..|.....::.|::|..|...:...|:|::|||:.|.:..::|||||:|:.||||::
  Rat   411 VTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR 475

  Fly   476 SPVVH-MSYIAANNLDVYAVILGTIVALCFIT--------KLLFGLVVGKLR-KNSRKAKVN 527
             |..| :::...::|||...:|..::.:.||.        :..||   ||.| |.|.|:|.:
  Rat   476 -PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFG---GKGRVKKSHKSKTH 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	150/567 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	137/517 (26%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	145/552 (26%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	82/254 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910