DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-39

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504816.2	Gene:	ugt-39 / 3564933	WormBaseID:	WBGene00017329	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	141/550 - (25%)
Similarity:	241/550 - (43%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSL------------HKDINHILVPM 75
            |.|......:.||.....::|..|.:.|||||..|    |::            .||:.| :.|.
Worm    18 NFLVFCPLFAHSHSKFFATIADSLTDAGHNVTFFT----PTIVEKYRNVSYTKSTKDVVH-MKPS 77

  Fly    76 EEDILQAFNSVV--GGMTK--TDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKDLYEHPDNKF 136
            ::  |:.:...:  |...:  |::|.| ..:...||...:.:::.|.|||.. |..|.|....||
Worm    78 KK--LKEYGEQMSTGDFVRYWTEDSTA-TEIIPVVRIFQKMYNEQGTVMKDN-VGILNELKKRKF 138

  Fly   137 DLVMV-GYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLGNPWEVSYVPGMSVSIKGGKPL--- 197
            |:::. .|..:.|  .|...|::|..:     ||           ||.....|::|:.|:|:
Worm   139 DVIIFEAYIYSAY--PLMDYLEIPTFI-----PS-----------VSVAHDTSLAIEIGEPVMPS 185

  Fly   198 -------GFGHRVLNLLGSMAQRLF-MFIIELRNARIYREIYGDDPTLPSYEDLHKNI------- 247
                   .||.::     |:.:|.| .|::.      |.:.....||..|::..:..|
Worm   186 VVSDCLSPFGDKL-----SITERAFNAFMVP------YFDFMIGYPTHRSFKPPYNPIDIRSIVP 239

  Fly   248 --SLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSE---APNGAILLSLGSN 307
              |.:|..|:...:.| ||.:...|:||||.| :..|...|.:::..||   .....:|:|.||.
Worm   240 EASFVFLNSNPFVDFP-RPTLTKTIQIGGISV-DSNELRSQKLDETWSEILKLREKTMLVSFGSM 302

  Fly   308 L--KEDHLKSSTVQKMFNVLSKLQQ-KVIWKWDD--LDNIPGESENILYSKWVPQVDVLAHPNIT 367
            |  |:...|:....|  |.:.|.:. ..|||::|  .|......|||.::|||||..:||...::
Worm   303 LYSKDMPFKNKIALK--NAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSRLS 365

  Fly   368 LFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTL-EEDSFLQGIREVL 431
            .|:||||.|.:.|..|.|||.:..|...||..||.::|.|...|:.|...| :.:..:...:.:|
Worm   366 AFLTHAGLGSINELSYLGKPAILCPQLFDQMRNAKMLVRHNGSIELSKYDLGDSEKIVNAFQAIL 430

  Fly   432 DNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVIL 496
            .:..||......:....::|:.|:|.::...|:..|:...|.:......|::|....:||.|:.:
Worm   431 FDSSYAKNALKLAEQLENQPIKPKEMMVKHAEFAARFGRLPSLDPYSRKMTFIEYFLIDVAAISM 495

  Fly   497 GTIVALCFITKLLFGLVVGKLRKNSRKAKV 526
            ..::|:.|:...:|.::   ..|.|.|.|:
Worm   496 VVLIAVVFVITKMFKIL---CNKTSVKGKI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	139/545 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	130/505 (26%)
ugt-39	NP_504816.2	Glycosyltransferase_GTB_type	12..503	CDD:299143	135/526 (26%)
ugt-39	NP_504816.2	UDPGT	29..521	CDD:278624	138/536 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910