DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	162/567 - (28%)
Similarity:	254/567 - (44%)	Gaps:	97/567 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAE---RGHNVTVVTILKP-------P 62
            |.|||...:..|....:|     :.|......|::..||.|   |||.|||   |||       |
  Rat    10 LLLQISFCLRSAKCGKVL-----VWPMEFSHWMNIKTILDELVQRGHEVTV---LKPSAYYVLDP 66

  Fly    63 SLHKDINHILVP---MEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSK------MGD 118
            ....|:.....|   .::::.:.|..:|...|.....:..:|....::.:.:.||.      ...
  Rat    67 KKSPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKDA 131

  Fly   119 VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSF-----LGYLLGNP 178
            |..:.|:..|.|   :|||:::......|.:| :|..|.:|.:.:|...|..     .|..:..|
  Rat   132 VSNKQLMAKLQE---SKFDVLLSDPVAACGEL-IAEVLHIPFLYSLRASPGHKIEKSSGRFILPP 192

  Fly   179 WEVSYVPGMSVSIKG-GKPLGFGHRVLNLLGSMAQRLFMFIIELRNAR----IYREIYGDDPTLP 238
               ||||   |.:.| |..:.|..||.|::   ....|.|...:.||:    .|.||.|...||.
  Rat   193 ---SYVP---VILSGLGGQMTFIDRVKNMI---CMLYFDFWFHMFNAKNWDPFYTEILGRPTTLA 248

  Fly   239 ------------SYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQ 290
                        ||.||               |.| .|.:|.|..|||:|.|  |.: ||:::|.
  Rat   249 ETMGKAEMWLIRSYWDL---------------EFP-HPTLPNVDYIGGLQCK--PAKPLPKDIED 295

  Fly   291 FL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFN----VLSKLQQKVIWKWDDLDNIPGE-SENI 349
            |: |...:|.::.||||      :.||..::..|    .|:::.|||:||:|  ..||.. ..|.
  Rat   296 FVQSSGEHGVVVFSLGS------MVSSMTEEKANAVAWALAQIPQKVLWKFD--GKIPATLGPNT 352

  Fly   350 LYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQS 414
            ...||:||.|:|.||....|:||.|..|:.||.|||.||:.:|:||:|..|...||..|..:..:
  Rat   353 RVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLN 417

  Fly   415 ILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVV 479
            |.|:.:......::||::||.|.......||::.|:|:.|.:..|:|:|||:|:..|.|:: |:.
  Rat   418 IRTMSKSDLFNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLR-PLG 481

  Fly   480 H-MSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGKLRKNSRKAK 525
            | :.:...::|||...:|..:..:..:....|..:.....|..:|.|
  Rat   482 HNLPWYQYHSLDVIGFLLACLAVIAALAVKCFLFIYRFFAKKQKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	157/559 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	150/518 (29%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	155/550 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910