DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	155/538 - (28%)
Similarity:	255/538 - (47%)	Gaps:	78/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHILVPME-EDILQAFNSVVGGMTKTDNSN 97
            ||.:...::...||.|||.|||   ||.||:..|.:. |.|:: |:|...:.:.|......:..|
  Rat    34 SHWLNLKTILEELAARGHEVTV---LKYPSIIIDQSK-LTPLQFENIPVLYETEVAENHLNEIVN 94

  Fly    98 AYV------SMFRSVRQLSETFSKMGDVMKQPLVKDLYEHP------DNKFDLVMVGYFMNCYQL 150
            ..|      |::.:.|.|.:.|.::....:......||...      |.|:|::::...:.|.:|
  Rat    95 LAVNVIPNLSLWEAARTLQDFFLQLTGNFEDLCRSTLYNQTLMNKLRDAKYDVMVLDPVIPCGEL 159

  Fly   151 ALAHKLKVPLVVALSNPPSF-LGYLLGN-----PWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGS 209
             :|..|::|.|    |...| :||.:..     |..:||||.:...:.  ..:.|..||.|::.|
  Rat   160 -VAEVLQIPFV----NTLRFSMGYSMEKYCGQLPVPLSYVPVVMGELT--DHMTFTERVKNMMLS 217

  Fly   210 MAQRLFMFIIELRNARIYREIYGDD---PT-------------LPSYEDLHKNISLIFFASHGIS 258
            :   .|.|.::..:...:.:.|...   ||             :.:|.|:
  Rat   218 L---FFEFWLQQYDFAFWDQFYSKTLGRPTTFCKTVGKAEIWLIRTYWDI--------------- 264

  Fly   259 EGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKM 321
            |.| ||.:|....:||:..|  |.: ||:.:|:|: |...:|.::.||||.:|  :|.......:
  Rat   265 EFP-RPYLPNFEFVGGLHCK--PAKPLPKELEEFVQSSGEHGVVVFSLGSMIK--NLTEEKANLI 324

  Fly   322 FNVLSKLQQKVIWKWDDLDNIP-GESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHG 385
            .:.|:::.|||:|::....... |.:..||  .|:||.|:|.||....||||.|..|:.||.|||
  Rat   325 ASALAQIPQKVLWRYSGKKPATLGPNTRIL--NWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHG 387

  Fly   386 KPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDR 450
            .||:.:|:|||||.|...|...|..:|.:|.|:.....|..:|.|::.|.|.......|.::.|:
  Rat   388 VPMVGIPMFGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVINEPSYKENAMRLSRVHHDQ 452

  Fly   451 PLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF-ITKL-LFGLV 513
            |:.|.:..::|:|:|:|:.||.|::.....:|:...::|||...:|..:|.|.| |||. ||  :
  Rat   453 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLVCVVTLTFVITKCSLF--M 515

  Fly   514 VGKLRKNSRKAKVNQKHK 531
            ..|.....||.|.|:|.|
  Rat   516 CRKCCLRERKKKGNRKKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	149/528 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	135/486 (28%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	148/522 (28%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	82/243 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840