DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	153/557 - (27%)
Similarity:	263/557 - (47%)	Gaps:	72/557 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDI 68
            ||..|.|||.......:...:  |...|..||.:....:...|.:|||.|||   |:|.|
  Rat     6 ISALLLLQISFCFRSGNCGKV--LVWPLEYSHWMNLKIILDELVQRGHEVTV---LRPSS----- 60

  Fly    69 NHILVPMEED--ILQAF------NSVVGGMTKTDNSNAY-VSMFRSVR---QLSETFSKMGDVMK 121
            :..|.|.:..  :.:.|      :.|....|:..|:..| |..:..:|   .|::.|.:..|:..
  Rat    61 SVFLDPKKASGLVYETFPTTSNNDEVEKFFTQWVNTWTYDVPKYTCLRYYPSLNKMFGQFSDLWL 125

  Fly   122 QPLVKDLYEH-------PDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSF-LGYLL--- 175
            | |.:::..:       .:::||:|:......|.:| :|..|::|.|.:|    .| :||.:
  Rat   126 Q-LCREVVSNKHLMAKLKESQFDVVLSDAVGPCGEL-IAEILQLPFVYSL----RFGIGYGIEKY 184

  Fly   176 --GNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNAR----IYREIYGDD 234
              |.|:..||||.:...:.|  .:.|..||.|:|..:   .|.|..|...|:    .:.||.|..
  Rat   185 SAGQPFPPSYVPIILSGLSG--QMTFMERVENMLCLL---YFDFWFESFPAKDWDPFFSEILGRP 244

  Fly   235 PTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPN 297
            .|:   .|..|...:....|:...|.| ||::|.:..:||:..  ||.: ||:.||.|. |...:
  Rat   245 TTM---VDTMKKAEIWLIRSYWDLEFP-RPSLPNIEFVGGLHC--QPAKPLPKEMEDFAQSSGEH 303

  Fly   298 GAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDL--DNIPGESENILYSKWVPQVDV 360
            |.::.||||.::  ::.......:.:.|:::.|||.|:::..  |.:   ..|....||:||.|:
  Rat   304 GVVVFSLGSMIR--NITQERANTIASALAQIPQKVFWRFEGKKPDTL---GPNTRVFKWIPQNDL 363

  Fly   361 LAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQ 425
            |.||....|:||.|..|:.|:.:||.||:.:|:|.:|..|...||..|..:.....|:.....|.
  Rat   364 LGHPKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLN 428

  Fly   426 GIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH-MSYIAANNL 489
            .::.|::.|.|...|...|.::.|:||.|.:..::|:|:|:|:.||.|:: |:.| :::...::|
  Rat   429 ALKAVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLR-PLAHNLAWYQYHSL 492

  Fly   490 DVYAVILGTIVALCFIT----KLLFGLVVGKLRKNSR 522
            ||...:|..::|:..:.    ..|:...| |:.||.|
  Rat   493 DVIGFLLACVLAIVLLAVKCCLFLYRFFV-KVAKNKR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	148/549 (27%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	136/503 (27%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	145/536 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910