DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	154/538 - (28%)
Similarity:	259/538 - (48%)	Gaps:	77/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHLVIQMSMARILAERGHNVTVV----TILKPPSLHKDINHIL--VPM-EEDILQAFNSVVGGMT 91
            ||.:....:...||:|||.|||:    :||..|:....||..:  ||: :.|:..:|...:...|
  Rat    34 SHWINIKIILNELAQRGHEVTVLVSSASILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWT 98

  Fly    92 KTDNSNAYVSMFRSVRQLSETFSKMGDVMK---------QPLVKDLYEHPDNKFDLVMVGYFMNC 147
            :...:   :|::....::.:.|::..||::         :.|:|.|   ..::||:::......|
  Rat    99 RDFET---LSIWTYYSKMQKVFNEYSDVVENLCKALIWNKSLMKKL---QGSQFDVILADAVGPC 157

  Fly   148 YQLALAHKLKVPLVVALSNPP-----SFLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLL 207
            .:| ||..||.|||.:|...|     .|.|   |.|...||||.:...:  ...:.|..||.|:|
  Rat   158 GEL-LAELLKTPLVYSLRFCPGYRCEKFSG---GLPLPPSYVPVVLSEL--SDRMTFVERVKNML 216

  Fly   208 GSMAQRL-----FMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVP 267
                |.|     |....|...::.|.::.|...||   .::.....:....:....|.| .|.:|
  Rat   217 ----QMLYFDFWFQPFKEKSWSQFYSDVLGRPTTL---TEMMGKADIWLIRTFWDLEFP-HPFLP 273

  Fly   268 AVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQ 330
            ....:||:..|  |.: ||:.||:|: |...:|.::.||||.:|  :|.......:.:.|:::.|
  Rat   274 NFDFVGGLHCK--PAKPLPREMEEFVQSSGEHGVVVFSLGSMVK--NLTEEKANVVASALAQIPQ 334

  Fly   331 KVIWKWDDLDNIPGESENILYS-----KWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLA 390
            ||:|::|      |:..:.|.|     ||:||.|:|.||....|:.|.|..|:.||.|||.|::.
  Rat   335 KVVWRFD------GKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIVG 393

  Fly   391 LPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPR 455
            :|:|.|||.|.:.||..|..::.....|.....|..::.|:::|.|.......|.::.|:|:.|.
  Rat   394 IPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRLSRIHHDQPVKPL 458

  Fly   456 ETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF-ITKL-LFGLVVGKLR 518
            :..::|:|||:|:.||.|::|.:..:|:...::|||...:|..:|.:.| |||. ||     ..|
  Rat   459 DRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGVVFIITKFCLF-----CCR 518

  Fly   519 KNSRKAKVNQKHKLKKKQ 536
            |.:...|       |||:
  Rat   519 KTANMGK-------KKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	150/523 (29%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	136/481 (28%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	151/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910