DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	159/555 - (28%)
Similarity:	259/555 - (46%)	Gaps:	93/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAE---RGHNVTVVTILKPPSLH 65
            ||....|||.......|...:|     :.|......|::..||.|   |||.|||   |||.:.
  Rat     6 ISALFLLQISYCFKSGHCGKVL-----VWPMDFSHWMNIKIILDELVQRGHEVTV---LKPSAY- 61

  Fly    66 KDINHILVPMEEDILQAFNSVVGGMTKTDNSNAYVSM-----FRSVRQLSETFSKMGDVMKQPLV 125
                ..|.|.:...|: |......::|.:..|.::.:     :...|....::|        |::
  Rat    62 ----FFLDPKKSSDLK-FEIFSTSISKDELQNHFIKLLDVWTYELPRDTCLSYS--------PIL 113

  Fly   126 KDL-YEH---------------------PDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPP 168
            ::| ||.                     .::|||::......:|..| :|..|.:|.:.:||..|
  Rat   114 QNLVYEFSYFYLSICKDAVSNKQLMTKLQESKFDVLFADPVASCGDL-IAELLHIPFLYSLSFSP 177

  Fly   169 SF-----LGYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNAR--- 225
            ..     :|..:..|   ||||.:...:.|  .:.|..||.|::   ....|.|..|:...:
  Rat   178 GHKLEKSIGKFILPP---SYVPVILSGLAG--KMTFIDRVKNMI---CMLYFDFWFEILRHKEWD 234

  Fly   226 -IYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNM 288
             .|.||.|...|:   ::....:.:....|:...:.| .|.:|.|..|||:..|  |.: ||::|
  Rat   235 TFYSEILGRPTTV---DETMSKVEIWLIRSYWDLKFP-HPTLPNVDYIGGLHCK--PAKPLPKDM 293

  Fly   289 EQFL-SEAPNGAILLSLG---SNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGE-SEN 348
            |:|: |...:|.::.|||   ||:.|:  |::.:..   .|:::.|||:||:|  ...|.. ..|
  Rat   294 EEFVQSSGEHGVVVFSLGSMVSNMTEE--KANAIAW---ALAQIPQKVLWKFD--GKTPATLGPN 351

  Fly   349 ILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQ 413
            ....||:||.|:|.||....|:||.|..||.||.|||.||:.:|:|||||.|...||..|..:..
  Rat   352 TRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFGDQPDNIAHMVAKGAAVSL 416

  Fly   414 SILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPV 478
            :|.|:.:..||..:.||:|||.|...|...||::.|:|:.|.:..::|:|:::|:.||.|:: |:
  Rat   417 NIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVFWIEFIMRHKGAKHLR-PL 480

  Fly   479 VH-MSYIAANNLDVYAVILG--TIVALCFITKLLF 510
            .| :.:...::|||...:|.  .::|...:..|||
  Rat   481 GHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	155/547 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	146/515 (28%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	153/537 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910