DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	555	Identity:	162/555 - (29%)
Similarity:	256/555 - (46%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVV----TILKPPSL 64
            ||..|.|||......|....:  |...:..||.:....:...|.::||.|||:    :|...|..
Mouse     6 ISALLLLQISCCFRSAKCGKV--LVWPVDYSHWMNIKIILDELKQKGHEVTVLRPSTSIFLDPKK 68

  Fly    65 HKDINHILVP--MEEDILQ-AFNSVVGGMT---KTDNSNAYVSMFRSVRQLSETFSKMGD----- 118
            ...:.....|  ...|::: .|...|...|   ..|...:|..:.:::      |.:..|
Mouse    69 SPGLKFETFPTSFSNDVMEIIFAKAVERWTYEVPRDTCLSYSPLLQNI------FDEYSDYCLTL 127

  Fly   119 ----VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLL---- 175
                |..:.|:..|.|   :|||:::......|.:| :|..|::|.:.:|...|   ||.|
Mouse   128 CKDTVSNKQLMAKLQE---SKFDVILSDAIGPCGEL-IAELLQIPFLYSLRFSP---GYYLEKYS 185

  Fly   176 -GNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMF--IIELRNARIYREIYGDDPTL 237
             |.|...||||.:...:.|  .:.|..||.|:: .|....|.|  ..|.:..:.|.|..|...||
Mouse   186 GGLPLPPSYVPVILSGLSG--QMTFKERVKNMI-CMLYFDFWFQTFREKKWDQFYSETLGRPTTL 247

  Fly   238 PSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAI 300
              .|.:.| ..:....|:...|.| .|.:|.|..:||:..|  |.: ||:.||.|: |...:|.:
Mouse   248 --IETMGK-AEMWLIRSYWDLEFP-HPTLPNVYYVGGVHCK--PAKPLPKEMEDFVQSSGEHGVV 306

  Fly   301 LLSLG---SNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGE-SENILYSKWVPQVDVL 361
            :.|||   ||:.|:  |::.:..   .|:::.|||:|::|  ...|.. ..|....||:||.|:|
Mouse   307 VFSLGSMVSNMTEE--KANAIAW---ALAQIPQKVLWRFD--GKTPATLGPNTRIYKWLPQNDLL 364

  Fly   362 AHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQG 426
            .||....||||.|..||.||.:||.||:.:|:||:|..|...||..|..:..:|.|:.....|..
Mouse   365 GHPKTKAFITHGGANGLYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDLLNA 429

  Fly   427 IREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDV 491
            :.||:|||.|.......||::.|:|:.|.:..::|:|:|:|:.||.|::....::::...::|||
Mouse   430 LEEVIDNPFYKENAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWYQYHSLDV 494

  Fly   492 YAVILG---TIVAL---CFITKLLFGLVVGKLRKN 520
            ...:|.   .||||   ||:....|.:...|..||
Mouse   495 IGFLLAFVTFIVALIVKCFLFVYRFFVKKEKKMKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	157/547 (29%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	142/501 (28%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	150/528 (28%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	153/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840