DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-56

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506074.2	Gene:	ugt-56 / 188073	WormBaseID:	WBGene00011453	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	143/554 - (25%)
Similarity:	231/554 - (41%)	Gaps:	140/554 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHLVIQMSMARILAERGHNVTVV-TILK---PPSLHKDINHIL-VPMEEDILQAFNSVVGGM-TK 92
            ||:.....:|.:||.|||.|||: .:.:   ...|..||:.|: |....::.:..|:  |.: |.
Worm    31 SHVYFTARIANVLAARGHKVTVIDNVFRYDVDNELSSDIHEIISVEPSPEVTKLLNT--GSLPTI 93

  Fly    93 TDNSNAYVSMFRSVRQLSETFSKMGDVMK---------QPLVKDLYEHPDNKFDLVMVGYFMNCY 148
            ..||.|.....|::.:      .:|.|.:         ..|:..|.|   .|||..:...|.:|
Worm    94 LWNSKASPEEQRTIME------GLGHVHRLQCTHLIENSTLIPKLQE---IKFDFAIHEVFDSC- 148

  Fly   149 QLALAHKLKVPLVVALSNPPSFLGYLLGNPWEVSYVP---GMSVSIKG-------GKPLGF--GH 201
            .:.:...:.|...|.:|:.         .|.:|  ||   |:|.::..       |..|.|  ..
Worm   149 GVGILEVIGVQKTVIVSST---------GPMDV--VPITLGISDTLNTPSLLSDYGSYLSFFEKR 202

  Fly   202 RVLNLLGSMAQRLFMFIIELRNARI---YREIYG-DDPTLPSYEDLHKNISLIFFASHGISEGPI 262
            |.|..|..|     :...|::::.|   :::.|| ..||    .::.:..:|:|:..|..|:| :
Worm   203 RNLKFLSGM-----LNFHEMQDSMISPLFKKYYGLKKPT----GEIMRQANLLFYNIHEGSDG-M 257

  Fly   263 RPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDH----LKSS---TVQK 320
            |.......:||||..|:| :.|....:..||: |...:|:|.|:.....|    ||:|   .:::
Worm   258 RMRGRRSFDIGGIAFKDQ-KNLTMEYQTLLSD-PRPKVLVSFGTAATSSHMPQNLKNSLMTAMKQ 320

  Fly   321 MFNVLSKLQQKVIWKWDDLDNIPGESE---NILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQ 382
            |.|||      .|||::..||...:.|   ||::.|::||.|:||...|.||:||.|:..|.||.
Worm   321 MNNVL------FIWKYEMEDNFTKQEELTTNIIFKKFLPQTDLLASSKIDLFVTHCGQNSLLEAF 379

  Fly   383 YHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVL-----DNP-KYATAVK 441
            ..|..:||:|:||||..||.:                  :|..|:.|:|     :.| |...|||
Worm   380 NSGVRVLAVPLFGDQHRNAKL------------------AFENGLIEILPKSDIETPAKIVKAVK 426

  Fly   442 S--------------FSTLYRDRPLSPRETLI------YWVEYVIRYHGAPHIQSPVVHMSYIAA 486
            :              .|:|.|:...:....||      |..|:...:...|....|
Worm   427 TGLEPNAKLDQNIVLISSLLRNSKENAENLLISTIEATYSTEFPPNFSKFPKNYHP--------- 482

  Fly   487 NNLDVYAVILGTIVALCFITKLLFGLVVGKLRKN 520
            |.|   ..::.:.:||.|:  |...:.|...|||
Worm   483 NTL---VRLIDSSIALVFM--LFIFVFVNHFRKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	143/554 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	133/515 (26%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<216..>399	CDD:299143	65/195 (33%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<353..453	CDD:299143	36/117 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910