DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-40

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	145/566 - (25%)
Similarity:	239/566 - (42%)	Gaps:	83/566 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLH 65
            |.|.|  |.|..::||:.....|||........||......:|.||.|.|||   ||:..|..:.
Worm     1 MKGFS--LYLYYLLLISSTTSYNILVFCPLFGHSHSTFFGRLADILTEAGHN---VTLFSPTIID 60

  Fly    66 KDINHILVPMEEDI--------LQAFNSVVGGMTKTDNSNAYV-------SMFRSV-RQLSETFS 114
            :..|:....:.:|:        |:|...::.|..:..|....|       ..|:|: |:.:...:
Worm    61 EFRNYSYTKLTKDVAYLDPSPELKAIGDLIAGNKRWWNQEFSVFEIPQTTRFFKSITREQNNVLA 125

  Fly   115 K---MGDVMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKV---PLVVALSNPPSFLGY 173
            .   :.|.:||           .||||::......| .|.|...|::   .:..:::..|..||
Worm   126 NNLALLDGLKQ-----------KKFDLILFESVFTC-ALPLMEYLEIKSFAVAQSIAYEPITLG- 177

  Fly   174 LLGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPT-L 237
            .||:....|::|.:..  :....:....|:||.|          |..:.|      :||..|. .
Worm   178 ALGDTVMTSHIPNLMA--QSSDKMSLCERMLNTL----------IQAMLN------VYGMTPEYY 224

  Fly   238 PSYEDLHKNI---------SLIFFASHGISEGPIRPNVPAVIEIGGIQVK----EQPERLPQNME 289
            .||.:..|.|         |.||..|:...:.| |..:...|:||||.|.    :...:|.:..:
Worm   225 QSYTNPEKKIYTLEKLSEASFIFMNSNPFLDFP-RATITKNIQIGGISVNLDTLKSSGKLTEEWD 288

  Fly   290 QFLSEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQ-KVIWKW--DDLDNIPGESENILY 351
            |.|: .....:|:|.||.:....:..:....:.|.:.:|.. ..|||:  ||........:||.:
Worm   289 QILN-LREKTLLVSFGSVILSQDMPFAYKVGLTNAMKQLNDVTFIWKYEGDDKKEFANGIKNIHF 352

  Fly   352 SKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSIL 416
            ||||||.::||.|.::.|:||.|.|.:.|..|.|||.:..|:.|||..||.::..|...|:.|..
Worm   353 SKWVPQRELLADPRLSAFMTHGGLGSVNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEFSKY 417

  Fly   417 TLEEDSFL-QGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVH 480
            .|..:..: ...|::|.:..|..:.|..|...:.:|:.|:|..:..||:..|:...|.:......
Worm   418 DLHNEKVVANAFRKILYDESYTLSAKRLSEHLQFQPVKPKELFLKHVEFAARFGKLPSLDPYSRQ 482

  Fly   481 MSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGKLRKNSRKAKV 526
            |.:|....:|:..::|  .|.|..::.|.|.|   |...:..|||:
Worm   483 MGFIQYFLIDIAFIVL--TVVLTIVSVLYFVL---KFVASCLKAKI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	137/550 (25%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	128/509 (25%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	116/460 (25%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	72/259 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910