DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-15

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506211.1	Gene:	ugt-15 / 183462	WormBaseID:	WBGene00008097	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	138/581 - (23%)
Similarity:	238/581 - (40%)	Gaps:	119/581 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALQIV----VLI----AGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSL 64
            |.|::|    ||:    .||..:|.||              .::.||.:.||:||
Worm    10 LLLELVCSYKVLVFNPAFGASHSNFLG--------------KISDILIDAGHDVT---------- 50

  Fly    65 HKDINHILVPMEEDILQAFNSVVGGM--------------------TKTDNS--------NAYVS 101
                  :|:|:   .:::...:||..                    .||:..        :|.::
Worm    51 ------MLIPV---CMESKKDLVGSKKVKKIIRIDQEPRSKLMQEEAKTEEMIKKQIWKLDADIT 106

  Fly   102 MFRSVRQLSETFS-----KMGDVMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLV 161
            :|.|   :.:.||     :..::.||..:  |.:..:..|||.:......| ...|...:.|..:
Worm   107 IFFS---MIKNFSIASGYQCENIFKQTAI--LEQLRNEHFDLGITESLFIC-GFPLLDSIGVKTI 165

  Fly   162 VALSNPPSFLGYL------LGNPWEVSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLF---MF 217
            :   |..|.| ||      ||.|...||.||  |..|....:.|..||.||.|......|   .|
Worm   166 I---NADSVL-YLDVVKHALGEPASTSYYPG--VYAKNIDRMSFRERVRNLFGMAFSWYFSWTRF 224

  Fly   218 IIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQV---KE 279
            ..||...:.|   |....|   :||.....:..|..|:...:.| .|.:|..:.|||:||   |.
Worm   225 QGELEAIKPY---YNKSLT---WEDHINGAAYYFINSNQYLDYP-SPTLPKTVFIGGMQVNTNKH 282

  Fly   280 QPERLPQNMEQFLSEAPNGAILLSLGSNL----KEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLD 340
            ...:|.:..:..|:..... :|:|.|||.    ..|..|.|.: |:|  .|..:...|||::..:
Worm   283 GKVKLEKEWDDLLNLRKQN-VLVSFGSNAFSCDMPDEFKESFL-KVF--ASMPETTFIWKYEQEN 343

  Fly   341 -NIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVM 404
             .:..:..|:..:.|:||.|:||...:|||:||.|.|...|..|.|||.:.:|:..|||.||.::
Worm   344 ATLADQLSNVKLTTWMPQNDILADERLTLFVTHGGLGSSMELAYQGKPAVVIPLMADQPRNALML 408

  Fly   405 VMHGFGIKQSILTL-EEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRY 468
            ..||..::.....| ..:...:.|:.|::||.|....:..:.:...:|..|::.::...::.:::
Worm   409 TRHGGALQLDKTFLNNSEKIREAIQTVMENPSYKKNAEKLANILSSQPHQPKDVVLKHCDFAVKH 473

  Fly   469 HGAPHIQSPVVHMSYIAANNLDV---YAVILGTIVALCFITKL-LFGLVVGKLRKNSRKAK 525
            .....:.|...|::.....::|:   ..:.|.||::....|.: :|..|....|.:.:|.:
Worm   474 GDLKTLNSEGRHLNVFQYYSIDIALAAGLFLVTIISFIIFTIIFVFKKVYFMCRSDKQKVE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	135/573 (24%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	127/528 (24%)
ugt-15	NP_506211.1	UDPGT	19..506	CDD:278624	128/542 (24%)
ugt-15	NP_506211.1	Glycosyltransferase_GTB_type	<252..493	CDD:299143	64/245 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910