DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37B1 and ugt-57

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	599	Identity:	142/599 - (23%)
Similarity:	247/599 - (41%)	Gaps:	122/599 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQIVVLIAG----AHGANILGLFTSLSPSHLVIQMSMARILAERGHNV-TVVTILKP-------P 62
            ::|::|:.|    ....|||......:.....|...:|:.||.|.||| ::..:|.|       |
Worm     1 MRILILLLGLTQIVTSLNILVFLLGTNQFERNIFEFLAQQLALRHHNVISIKPVLIPEEPRLVKP 65

  Fly    63 SLH----KDINHIL-----VPMEEDILQA-------FNSVVGGMTKTDNSNAYVSMFRSVRQLSE 111
            .||    |.|.::|     .|:|:.:..|       |::.:....|..|::.|       :.|:
Worm    66 KLHLVREKVIKNVLNKDLFKPLEDAVPNAAWRSTYDFDNYLEPYYKAHNASCY-------KLLN- 122

  Fly   112 TFSKMGDVMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLV--------------- 161
              |.:.|.:|:           ...||.:| |..|....||.|.:.||.:
Worm   123 --SNLVDSLKK-----------ESLDLAIV-YSGNPCLNALTHLVAVPTIYFDTEGLTDETLIAA 173

  Fly   162 ---VALSNPPS--FL----GYLLGNPWE--VSYVPGMSVSIKGGKPLGFGHRVLNLLGSMAQRLF 215
               :.|..|||  |:    ||.:.|.::  |.|...|...:  |.|      .::.|.|...||
Worm   174 GAPIDLLTPPSHCFIAESKGYPILNLYKNSVCYFQEMIAQL--GLP------AVSSLVSSRHRL- 229

  Fly   216 MFIIELRNARIYREIYGDDPTLPSYEDLH--KNISLIFFASHGISEGPIRPNVPAVIEIGGIQVK 278
               ::.....|:|..|.......::.:::  |..|..:|.:......|.|.....||.:||:.:
Worm   230 ---LDEPITNIFRTDYTIKKRFKNFPNVNTLKQQSAAYFVNTDPLLEPPRALPLNVIPVGGLHI- 290

  Fly   279 EQPERLPQNMEQFLSEAPNGAILLSLG-----SNLKEDHLKSSTVQKMFNVLSKLQQ-KVIWKWD 337
            :.|:.|.......::.|..|.|::|.|     |.:.|.|.|:     :...|:.|.. ::.|:..
Worm   291 DHPKPLFSPWNTTIASAKEGLIIVSFGTQADSSKMSEYHAKA-----ILKALTNLNDYRIYWRIG 350

  Fly   338 --------DLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVF 394
                    |::.||   ::|..:.::||.|:|||.:..||:|:.|...:.||..||.|::.:|::
Worm   351 PNMHLDGIDIEKIP---KHINLTTFIPQNDLLAHKSCKLFVTNGGMSSVMEAVAHGVPIVGVPLY 412

  Fly   395 GDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLI 459
            |....|...:...|.||......|.|.|....:::||::.||....|..|..::.|..||....:
Worm   413 GSNRYNLQKVSNKGLGIVIDKDDLNEISLYGAMKKVLESAKYKNTAKEMSKEFKSRTTSPFAAAL 477

  Fly   460 YWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFI-TKLLFGLVVGKLRKNSRK 523
            :.::::.|:|...::| |.....|   ..:|.|.::|  |:.|..| ..|.|...:.....|.:.
Worm   478 HVIDHIGRHHSFAYMQ-PAFQPIY---TRVDFYLLLL--IILLPVIPLHLFFTFCIKSSAMNVQD 536

  Fly   524 AKVNQKHK--LKKK 535
            .||.:..:  |.||
Worm   537 NKVLEAERKFLPKK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	137/581 (24%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	126/539 (23%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	80/329 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910