DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-18

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	135/543 - (24%)
Similarity:	229/543 - (42%)	Gaps:	72/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHILVPMEEDILQA 82
            ||..:|.||              .::.||.:.|||   ||:|.|..|....:.:.....:|:::.
Worm    28 GASHSNFLG--------------KISDILIDAGHN---VTMLIPEYLITKKDFVGSKKVKDVVRI 75

  Fly    83 FNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLV-----------KDLYEHPDNK- 135
            ......|....:....::...|..|...|..|.:..|....|.           ||:.:...|:
Worm    76 GRDERAGKLFEEEGIEHMGRARVWRMDPEMMSLVTIVGSMNLAIGYQCEYIFQQKDIIDRLRNEH 140

  Fly   136 FDLVMVGYFMNCYQLALAHKLKVPLVV-ALSNP-PSFLGYLLGNPWEVSYVPGMSVSIKGGKPLG 198
            |||.:......| ..||...:.:..|: |.||. ...:.|..|.|..:||.||: .|....| :.
Worm   141 FDLAITESLFAC-PFALFDHIGIKNVINAESNLFKDAVKYAHGEPAAISYYPGL-FSPHDDK-MS 202

  Fly   199 FGHRVLNLLGSMAQRLFMFIIELRNARIYREI------YGDDPTLPSYEDLHKNISLIFFASHGI 257
            |..||.|::      ..:|...|..:|..:|:      |....|   :|||...::.....|:..
Worm   203 FVARVKNMI------TMLFTKYLYGSRYEKELEMIKPYYNGTET---WEDLFTGVAFNLINSNQY 258

  Fly   258 SEGPIRPNVPAVIEIGGIQV--KEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQK 320
            .:.| .|.:|..:.:||:||  .|...:|.......|:..... :|:|.|||.....:.....:.
Worm   259 IDYP-SPALPKTVFVGGMQVNTNEAKTKLSDEWNNILNIRKQN-VLISFGSNAFSSEMPEEFKKS 321

  Fly   321 MFNVLSKLQQ-KVIWKWDDLD-NIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQY 383
            ...|...:.: ..|||:::.: .:.....|:..:.|:||.|:||...:|||:||.|.|...|..|
Worm   322 FLYVFGNMPEITFIWKYEEANATLTSHLPNVKLTTWMPQNDLLADDRLTLFVTHGGLGSTMELAY 386

  Fly   384 HGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDS--FLQGIREVLDNPKYATAVKSFSTL 446
            .|||.|.:|:..|||.||.::..|| |..|...|:..||  .|:..:.||...||:...:..:.:
Worm   387 QGKPALIIPLMADQPRNAHMLKRHG-GCLQYHKTMLGDSEQLLKAFKTVLTERKYSENAQRLARI 450

  Fly   447 YRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYA--VILGTIV------ALC 503
            .||:|:||::.::...|:.:.:.....:.|...:::.....:.|:.:  |:|..:|      .|.
Worm   451 LRDQPVSPKDLVLKHCEFAVEHGALNSLNSRGRYLNTFQFYSFDIASSIVMLALLVLVFIYFTLL 515

  Fly   504 FITKLLFGLVVGKLRKNSRKAKV 526
            ||.||:..:.:      |:|.|:
Worm   516 FIFKLVARIFL------SQKTKM 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	133/538 (25%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	123/490 (25%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	127/515 (25%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	68/254 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910