DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-6

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	136/568 - (23%)
Similarity:	237/568 - (41%)	Gaps:	88/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQIV--VLIAGAHGANILGLFTSLSP----SHLVIQMSMARILAERGHNVT-----VV------T 57
            ||||  :.|:...|......|..:||    ||:.....:|..||..|::||     ||      |
Worm     2 LQIVLFLFISTLFGNAYSYKFLVISPVYGFSHMKYMAELANHLARAGNDVTYFQPFVVDEYHDHT 66

  Fly    58 ILKPPSL------HKDINHILVPMEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKM 116
            ::|..|:      |.::....:|.:           |.|....:|:.|.|...:...||:.....
Worm    67 LIKEKSIKIWNYYHDELGRQHIPSQ-----------GCMRDAWHSSWYQSDAGAAILLSKYLFPA 120

  Fly   117 GDVMKQPLVKDLYEHPDNK---FDLVMVGYFMNCYQLALAHKLKVPLVVA--LSNPPSFLGYLLG 176
            .:.|.:.:.:|...|.|.|   ||:|:...|..| .|.||..|::|.:::  ..|..:.|..:||
Worm   121 FEHMCRKMFEDTELHYDLKSRQFDVVLSEAFDFC-GLYLASYLEMPSIISTFTGNRLNALAPVLG 184

  Fly   177 NPWEVSYVPGMSVSIKGGKPLGFGHR--VLNLLGSMAQRL-----FMFIIELRNARIYREIYGDD 234
            .|..:.|:|..:..        :||.  :.:.|..:..::     |..:.|::..::.:...|
Worm   185 EPSFLHYLPAPTSQ--------YGHESTIFDRLNDVWHKIWSSYGFAQLFEMQYQQVSKLTNG-- 239

  Fly   235 PTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGA 299
             .:..::|:..:::..|..|:...:..| |.:|.|:.||||.|.........|..:.|....|..
Worm   240 -KVKHWKDIIHDVTYHFSNSNPYLDFVI-PTIPKVVPIGGITVDHDYWSTNGNHSELLEHVLNAR 302

  Fly   300 ---ILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQ-KVIWKWDDLDNIPGESE-------NILYSK 353
               :.:|.||.::...:.....:.|..|.|.... ..:||::    :|.:.|       |:..:|
Worm   303 KHNVFISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYE----LPNDQEFLRILPTNVHVAK 363

  Fly   354 WVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTL 418
            |..|..:|:...:.||:||.|.|...|.....||.:.:|:|.|||.||.::..||.....|.|.:
Worm   364 WFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHGSVEIFSKLDI 428

  Fly   419 EEDSFLQGIREVLDNPKY--ATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHM 481
            .....|..:.:.:.|.||  ..|.:...|| |.:|::|.:.::...|...|:...|::......|
Worm   429 PNSKKLSSLIQKMLNTKYYQQNANRLADTL-RFQPITPTDLMVKHAENAARFGKMPNLVPHAKDM 492

  Fly   482 SYIAANNLDVYAVILGTIVALCFITKLLFGLVV---GKLRKNSRKAKV 526
            .:....|:|:..::.       .:..|||.:|.   .|| |.|.|.||
Worm   493 GFFEYYNIDIIFIVF-------LLVWLLFSVVAHVFSKL-KLSLKIKV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	131/561 (23%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	120/517 (23%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	108/463 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960