DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-5

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506200.1	Gene:	ugt-5 / 179753	WormBaseID:	WBGene00013906	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	147/563 - (26%)
Similarity:	250/563 - (44%)	Gaps:	106/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FTSLSP----SHLVIQMSMARILAERGHNVT-----VVTILKPPSLHKDINHILVPMEEDILQAF 83
            |..:||    ||:.....:|..||:.||.||     ||.:.|...|.|:.|       .:|:..|
Worm    23 FLVISPVYGFSHMKSMAIIANQLADAGHQVTYFQPFVVELFKDHDLIKNPN-------IEIMNYF 80

  Fly    84 N------SVVGGMTKTDNSNAY-------VSMFRSVRQLSETFSKMGDVMKQPLVKDLYEH---- 131
            :      ::.|....:|...:|       ..:| :.|.|.::|        |.:.:.::|.
Worm    81 HDEEGKKNIPGHSVLSDAWTSYKYQSDVGQKIF-APRILHQSF--------QEMCRHMFEDEALH 136

  Fly   132 ---PDNKFDLVMVGYFMNCYQLALAHKLKVPLVVAL--SNPPSFLGYLLGNPWEVSYVPGMSVSI 191
               .|.|||:|:...|..| .|.||..|::|.::::  .|..:.:...||.|..:.|:|..|.|.
Worm   137 RQLKDKKFDVVLSETFDFC-GLYLADYLEMPAIISVFTGNRLNAITNALGEPSFLHYLPSPSSSF 200

  Fly   192 KGGKPL-----GFGHRVL--NLLGSMAQRLFMFIIELRN--ARIYREIYGDDPTLPSYEDLHKNI 247
            .....|     .|.|::|  :..|.:..|.:..:..|.|  ||.:::|..|    .:|...:.|.
Worm   201 NANMSLYDRFNNFWHKILSSSTFGELFDRQYADVYRLTNGKARHWKQILND----VTYHFSNSNP 261

  Fly   248 SLIFFASHGISEGPIRPNVPAVIEIGG--IQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKE 310
            .|.|          :.|.:..||.|||  :..|:.|. :.::::..|: ..:..:.:|.|:.:..
Worm   262 YLDF----------VIPTIAKVIPIGGYTMDYKQVPP-VSKDLDTILN-LRSSTVFISYGTMISA 314

  Fly   311 DHLKSSTVQKMFNVLSKLQQKV--IWKWDD------LDNIPGESENILYSKWVPQVDVLAHPNIT 367
            .::.....|.|.:.. |..:.|  :||:::      .:|||   :|:..|.|.||..:||...:.
Worm   315 KYMPDEYKQSMIDFF-KDNKNVTFLWKYEEPEEKFIKENIP---DNVHLSTWFPQQSLLADKRVK 375

  Fly   368 LFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHG---FGIKQSILTLEEDSFLQGIRE 429
            |||||.|.|...|..|..||.:..|:|.||||||.::..||   ...|..|...::.|.|  ::.
Worm   376 LFITHGGLGSTMELAYSAKPAIVTPLFADQPSNAQMLERHGSVEVLSKHDIPNWKKQSDL--LKT 438

  Fly   430 VLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLD--VY 492
            :|.:.||..|....:.:..::|:||||.::...|...|:...|.:......|.:|...|:|  :|
Worm   439 MLADKKYQEAATRLADILNNQPISPRELMLKHAENAARFGKIPSLTPFAKDMGFIEFYNIDLIIY 503

  Fly   493 AVILGTIVALCFITKLLFGLVVGKLRKNSRKAKVNQKHKLKKK 535
            :|.. |:.|: ::|..:||:|     ||..|.:     |||.:
Worm   504 SVSF-TLFAI-YVTIEIFGIV-----KNCCKTR-----KLKNE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	143/549 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	130/507 (26%)
ugt-5	NP_506200.1	egt	6..509	CDD:223071	135/525 (26%)
ugt-5	NP_506200.1	UDPGT	32..527	CDD:278624	140/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960