DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt-29

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001370778.1	Gene:	ugt-29 / 178581	WormBaseID:	WBGene00021709	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	260/568 - (45%)	Gaps:	83/568 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPP---------SL 64
            :|...:|...:...|||....:.:.||......:|..|.|||||||.:..:..|         .|
Worm     5 SLIFTLLFCSSSSLNILVYSPAYAASHSNFLGKLADTLTERGHNVTYLMPVMDPGKRDECIGVKL 69

  Fly    65 HKDINHILVPMEEDILQAFNSV--------VGGMTKTDNSNA--YVSMF-RSVRQLSETFSKMGD 118
            .||:  ::|..:|:::.....|        :...::.|:||:  ..|.| .:::.....|.|..|
Worm    70 TKDL--VIVEADEEMMSREEGVTLDEEIMELYWKSEMDSSNSRDMFSFFNNAMKAACRNFLKRRD 132

  Fly   119 VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSN---PPSFLGYLLGNPWE 180
            :.:|        .....||:.:|.....| .|.....|.:...:..|:   ..|.:.| :|.|.:
Worm   133 IFEQ--------MKSRNFDVAIVEPLSVC-GLGFVKALGIEKTILASSCTFYDSIMDY-IGEPLD 187

  Fly   181 VSYVPGM-SVSIKGGKPLGFGHRVLNLLGSMAQRLFM---FIIELRNARIYREIYGDDPTLPSYE 241
            .||||.: ||:   |..:....|..|.:.:....:.:   |..|:::   |||..|.|  ||.:.
Worm   188 FSYVPALFSVT---GDVMTMSERYENWMVTKEINIGIHEKFDDEMKS---YREFLGQD--LPDWR 244

  Fly   242 DLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQV-----KEQPERLPQNMEQFLSEAPNGAIL 301
            :|....|:.|..|:...:.| ||.:...:.||||.|     |||  :|.::.|:.| |.....:|
Worm   245 ELLSTASIFFINSNPFFDFP-RPVLQKTVPIGGISVNLKWIKEQ--KLTKDWEEVL-EMRKKTVL 305

  Fly   302 LSLGSNLKEDHLKSSTVQKMFNVLSKLQQ-KVIWKW--DDLDNIPGESENILYSKWVPQVDVLAH 363
            :|.||.:|..::.......:.:|:..:.. ..|||:  ||:....|.| ||.:||||||..:|..
Worm   306 ISFGSLVKSAYMPKKWRNGLLDVIKSMPDVTFIWKYETDDVSFADGVS-NIHFSKWVPQTALLND 369

  Fly   364 PNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIR 428
            |.:::|:||.|.|...|..|.|||.:.:|||.||..||:::..|     :.::.|.::| ::.::
Worm   370 PRLSVFVTHGGLGSTMELAYSGKPAVVIPVFADQIRNANMIARH-----RGVIYLHKNS-MENVK 428

  Fly   429 -------EVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAA 486
                   :||.:..|....:..:.:..::|.||:|.:|.:.|::..:...|::.....|::|...
Worm   429 VTRKAFTDVLFDDSYQKNAEKLANILMNQPYSPKENVIKYTEFLGEHGPFPNMDPHGRHLNYFQK 493

  Fly   487 NNLDVYAVILGTIVALCFITKLLFGLVVGKLR---KNSRKAKVNQKHK 531
            ..||:|     |:.||.:|  .:..:::..:|   |.:||..:..|.|
Worm   494 TFLDIY-----TLFALFYI--FVSTIIIVTIRFVYKFTRKHFILVKSK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	143/555 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	133/511 (26%)
ugt-29	NP_001370778.1	GT1_Gtf-like	18..468	CDD:340817	129/480 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910