DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37B1 and ugt-24

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	134/550 - (24%)
Similarity:	236/550 - (42%)	Gaps:	75/550 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVV-TILKPPSLHKDI---- 68
            ||...:||.    :|:.|      .||:.:..::|..|.:.|||||:. .|::...|.|..
Worm    17 ALPYKILIY----SNLYG------HSHIKVLNTVADTLTDAGHNVTIFRPIIESSQLDKSSVKTK 71

  Fly    69 NHILVPMEEDILQAFNSV---VGGMTKTDN---------SNAYVSMFRSVRQLSETFSKMGDVMK 121
            |.|.:..:|::::..:.:   .|.:...|:         |||.|..|.         ::...||:
Worm    72 NVIYIEPDEEVVEKMSKIDQFSGSLWTFDSTHPSAMIAKSNALVGFFG---------TQCKKVMR 127

  Fly   122 QPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVALSNPPSF--LGYLLGNPWEVSYV 184
            |..:.|  :..|..|||.:......| ..|:...||:...|.:.:...|  :..:||.|...|||
Worm   128 QQKILD--QLRDENFDLAITEPVDGC-AYAIFEYLKIRDHVTVLSCVRFDHVSDILGQPIAPSYV 189

  Fly   185 PGMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFI-----------IELRNARIYREIYGDDPTLP 238
            ||....        |..|:     :|.:||..||           |..:...:.::|.|   ...
Worm   190 PGTQSF--------FNDRM-----TMKERLLNFIQFYYGRFTFANILDQEYEMAKDILG---IQR 238

  Fly   239 SYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVK--EQPERLPQNMEQFLSEAPNGAIL 301
            |:.::....|.||.....:.:.| .|....:|.|||..||  |:..::.:..:..|:..... :|
Worm   239 SWREVLPEASFIFSNHIPVLDFP-SPTFDKIIPIGGFTVKTNEKSLKIDKKWDAILNIRKKN-VL 301

  Fly   302 LSLGSNLKEDHLKSSTVQKMFNVLSKLQQKV-IWKWDDLD-NIPGESENILYSKWVPQVDVLAHP 364
            :|.|||.|...:.....:.:..|.|.:.... |||::|.: ||....:|:..|.|:||.::||..
Worm   302 ISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYEDPNVNIAKNLDNVFISSWLPQNELLADS 366

  Fly   365 NITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMH-GFGIKQSILTLEEDSFLQGIR 428
            .:|:|:||.|...:.|....|||.:.:|:|.||..||.::..| |..:.|.......|.....:.
Worm   367 RVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHGGAAVLQKTDLSNFDLVRDTLN 431

  Fly   429 EVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYA 493
            :||..|.|....|..:.:..::|.:.:|.|:..||:..|:...|.:.:...|.:.:....:|:..
Worm   432 DVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLPMLDNYGRHQNIVEYYFIDILT 496

  Fly   494 VILGTIVALCFITKLLFGLVVGKLRKNSRK 523
            :||..::::.:|...|...::.:.|....|
Worm   497 IILSVLISVFYIFVRLLRFMLSRNRSTKDK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	131/545 (24%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	125/504 (25%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	126/516 (24%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	67/254 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910