DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	152/534 - (28%)
Similarity:	255/534 - (47%)	Gaps:	54/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NILG---LFTSLSPSHLVIQMSMARILAERGHNVTV----VTILKPPSLHKDINHILVPME-EDI 79
            ::||   |......||.:....:...|:||||::.|    |.:|...|.:.......||.. |::
  Rat    22 SVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNLEEL 86

  Fly    80 LQAFNSVVGGMTKTDNSNAYVSMFRSVRQ----LSETFSKMGDVMKQPLVKD---LYEHPDNKFD 137
            ...:.|.  |......|:..::..|..|.    :...|...     |.|:||   |....:|:||
  Rat    87 RTRYRSF--GNNHFAASSPLMAPLREYRNNMIVIDMCFFSC-----QSLLKDSATLSFLRENQFD 144

  Fly   138 LVMVGYFMNCYQLALAHKLKVPLVVALSNPPSFLGYLLG-NPWEVSYVPGMSVSIKGGKPLGFGH 201
            .:.....|.| .:.||..||:|.|......|..|.::|| :|..|||||....  |....:.|..
  Rat   145 ALFTDPAMPC-GVILAEYLKLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYT--KFSDHMTFPQ 206

  Fly   202 RVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNV 266
            |:.|.:.::.:......:..:...:..::...|.:||:   ||:| ||.......:.|.| ||.:
  Rat   207 RLANFIANILENYLYHCLYSKYEILASDLLKRDVSLPA---LHQN-SLWLLRYDFVFEYP-RPVM 266

  Fly   267 PAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQ 330
            |.:|.|||...|:: ..|.|..|.:: :...:|.::.||||.:.|  :......::...|.::.|
  Rat   267 PNMIFIGGTNCKKK-GNLSQEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQ 328

  Fly   331 KVIWKWDDL--DNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPV 393
            .|:|::...  .|:   ::|.:..||:||.|:|.||....||||:|..|:.|...:|.||:.:|:
  Rat   329 TVLWRYTGTRPSNL---AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPL 390

  Fly   394 FGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETL 458
            ||||..||..|...|.|:..::|.:..|.....::.|::|..|...:...|:|::|||:.|.:..
  Rat   391 FGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLA 455

  Fly   459 IYWVEYVIRYHGAPHIQSPVVH-MSYIAANNLDVYAVILGTIVALCFIT--------KLLFGLVV 514
            ::|||||:|:.||||:: |..| :::...::|||...:|..::.:.||.        :..||
  Rat   456 VFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFG--- 516

  Fly   515 GKLR-KNSRKAKVN 527
            ||.| |.|.|:|.:
  Rat   517 GKGRVKKSHKSKTH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	150/528 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	137/479 (29%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	143/503 (28%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	145/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910