DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	585	Identity:	158/585 - (27%)
Similarity:	260/585 - (44%)	Gaps:	113/585 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAE---RGHNVTVVTILKPPSLH 65
            ||..|.|||...........:|     :.|......|::..||.|   |||.|||:.    ||.:
Mouse     6 ISALLLLQISCCFRSVKCGKVL-----VWPMEFSHWMNIKIILDELVQRGHEVTVLR----PSAY 61

  Fly    66 KDINHILVPMEEDILQAFNSVVGGMTKTDNSNAYVSM-----FRSVRQLSETFSKMGDVMKQPLV 125
                ::|.|.:...|: |.:....:||.|..|.::.:     :...|....::|        ||:
Mouse    62 ----YVLDPKKSPGLK-FETFPTSVTKDDLENFFIQLLNVWTYELSRDTCLSYS--------PLM 113

  Fly   126 KDLYEHPDNKFDLVMVGYFMN-CYQLALAHKLKVPLV-----VALSNPPSFLGYLLGNPWEV--- 181
            :::::.        :.||::: |..:....:|...|.     |.||:|.:|.|.|:.....:
Mouse   114 QNMFDE--------LSGYYLSLCKDVVSNRQLMTKLQESKFDVLLSDPVAFGGELIAELLHIPFL 170

  Fly   182 ----------------------SYVPGMSVSIKG-GKPLGFGHRVLNLLGSMAQRLFMFIIELRN 223
                                  ||||   |.:.| |..:.|..||.|::   ....|.|..::.|
Mouse   171 YSLRFTAGYRIEKSSGRFLLPPSYVP---VILSGLGGQMTFIERVKNMI---CMLYFDFWFQMPN 229

  Fly   224 AR----IYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER- 283
            .:    .|.|..|...||   .:......:....|:...|.| .|.:|.|..:||:..|  |.:
Mouse   230 DKKWDSFYTEYLGRPTTL---AETMGQAEMWLIRSNWDLEFP-HPTLPNVDYVGGLHCK--PAKP 288

  Fly   284 LPQNMEQFL-SEAPNGAILLSLG---SNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPG 344
            ||::||::: |...:|.::.|||   ||:.|:     .|..:...|:::.|||:||:|  ...|.
Mouse   289 LPKDMEEYVQSSGDHGVVVFSLGSMVSNITEE-----KVNAIAWALAQIPQKVLWKFD--GKTPA 346

  Fly   345 E-SENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHG 408
            . ..|....||:||.|:|.||....||||.|...:.||.|||.||:.:|:||:|..|...||..|
Mouse   347 TLGHNTRVYKWLPQNDLLGHPKTKAFITHGGANSVYEAIYHGIPMIGIPLFGEQHDNIAHMVAKG 411

  Fly   409 FGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPH 473
            ..:..:|.|:.....|..:.||::||.|.......||::.|:|:.|.:..::|||:|:|:..|.|
Mouse   412 AAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLDRAVFWVEFVMRHKNAKH 476

  Fly   474 IQSPVVH-MSYIAANNLDVYAVILGTIVALCFITK--LLFGLVVGKLRKNSRKAKVNQKHKLKKK 535
            :: |:.| :::...::|||...:|..:.|...:|.  |||          ..:..|.:|.|:|.:
Mouse   477 LR-PLGHNLTWYQYHSLDVIGFLLACVAATVVLTVKCLLF----------IYRFFVTKKKKMKNE 530

Fly 536 535
Mouse 531 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	149/563 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	139/520 (27%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	150/562 (27%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	35/156 (22%)
		egt	<270..489	CDD:223071	79/228 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840