DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	558	Identity:	161/558 - (28%)
Similarity:	262/558 - (46%)	Gaps:	90/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVLIAGA--HGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVT-----ILKPPSLHKDINH 70
            |::|.|:  .|..|  |...|..||.|....:.:.|..:||.|.|:.     .:|..|.:  .|.
Zfish    17 VMIIFGSLCDGGKI--LVAPLEGSHWVNMDILIKALHGQGHTVDVIRNTNSWFVKENSTY--YNS 77

  Fly    71 ILVP--------MEEDIL-------QAFNSVVGGMTK-TDNSNAYVSMFRSVRQLSETFSKMGDV 119
            |.:|        ..||:|       :...|.:||:.. .|.|.|.....:.|.:|.....:..|:
Zfish    78 ITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKLVCRLITNIFESEDI 142

  Fly   120 MKQPLVKDLYEHPDNKFDLVMV--GYFMNCYQLALAHKLKVPLV--VALSNPPSFLGYLLGNPWE 180
            :|.     |.|   .|:||::.  |:...   :.||||||:|:|  |..:.|..  |:....|..
Zfish   143 LKA-----LQE---KKYDLMLTDPGWGTG---IILAHKLKLPMVYNVRWTTPGE--GHFDIAPSP 194

  Fly   181 VSYVP--GMSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARI----YREI---YGDDPT 236
            :||:|  |...:.|    :.|..||:|:       .:..:::.:.:|.    |:.:   |.|.|.
Zfish   195 MSYIPLTGSGNTDK----MSFFQRVINV-------FYYLLLDFQCSRFNVPQYQALCDKYFDPPV 248

  Fly   237 LPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGA 299
              .:..|.:...|.......:.|.| ||.:|.:|..||.|.  .|.: ||.::|.|: |...:|.
Zfish   249 --DFYKLLQGADLWLMRVDFVFEFP-RPTMPNIIYTGGFQC--TPTKPLPHDLEDFMQSSGDHGV 308

  Fly   300 ILLSLGS--NLKEDHLKSSTVQKMFNVLSKLQQKVIWKW-----DDLDNIPGESENILYSKWVPQ 357
            |::||||  ::..|:: ||.:...|   ::|.|||||::     ..|.|      |.|...|:||
Zfish   309 IVMSLGSFISVLPDYV-SSEIAAAF---ARLPQKVIWRYTGKKPSTLGN------NTLLVDWMPQ 363

  Fly   358 VDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDS 422
            .|:|.||...|||.|.|..|:.||.|||.|::.:|.|.||..|...:...|.....|:..|.|:|
Zfish   364 KDLLGHPKTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENS 428

  Fly   423 FLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAAN 487
            ....|:||::.|.|...::..|.|:||:|:.|.::.|:|:|:|:|:.||.|:::....|.:.:.:
Zfish   429 LHAAIQEVINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYH 493

  Fly   488 NLDVYAVILGTIVALCFITKLLFGLVVGKLRKNSRKAK 525
            ::||...::.  |.|.||..:...:....::..|||.|
Zfish   494 SVDVSVTLIA--VVLIFIYSMFVTVRYLCIKCCSRKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	158/554 (29%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	151/514 (29%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	157/547 (29%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	87/254 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840