DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	566	Identity:	153/566 - (27%)
Similarity:	256/566 - (45%)	Gaps:	93/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVT-----ILKPPSLHK 66
            |....:.|..||..| |||..:|  ..||.:....:...|.:|||||||:.     .:|.....:
Zfish     6 CFLSLLTVFSAGQCG-NILVWYT--EGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDR 67

  Fly    67 -DINHILVPME-EDILQAFNSVVG-GMTKTDNSNAYVSMFRSVRQLSETFSKMGD---------- 118
             ...|..|... :|:...|:.::. .:.:.|||        |..::...|..:|.
Zfish    68 FSYQHFSVSKSAQDMQDFFDELMRFSVFEMDNS--------SFLEIQMKFFNLGSQHQDMSLSYC 124

  Fly   119 --VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVA---------------LSN 166
              ::|.|.:.|..:  ..|||:|:......|..: :|.:|.||||..               :..
Zfish   125 DGILKSPELMDKLK--KGKFDVVLSDPMYPCSDI-VAEELNVPLVYTFRFSVAHAAERMCGQIPA 186

  Fly   167 PPSFLGYLLGNPWEVSYVPG-MSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREI 230
            ||             ||||| ||   |....:.|..|:.|:|..::|.....:|..|....|.|.
Zfish   187 PP-------------SYVPGAMS---KLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDNYYTEY 235

  Fly   231 YGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-S 293
            :|..   .||.::.....:....::...|.| ||.||....|||:..  .|.: ||::||:|: |
Zfish   236 FGRS---TSYCEMMGKADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC--TPAKPLPKDMEEFVQS 294

  Fly   294 EAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGE-----SENILYSK 353
            ...:|.::.:|||.:  |.:......::.:.|:::.|||:|::.      ||     .||....|
Zfish   295 SGDDGIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYG------GEKPDTLGENTRIYK 351

  Fly   354 WVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFG-IKQSILT 417
            |:||.|:|.||....||||.|..|:.||.|||.||:.:|:|||||.|...|...... :..||.:
Zfish   352 WIPQNDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKS 416

  Fly   418 LEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMS 482
            ::....:..:..|:::|.|.......|.::.|||:.|.:..::|:|:|:|..||.|::....:::
Zfish   417 MQPQELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLT 481

  Fly   483 YIAANNLDVYA---VILGTIVALCFITKLLFGLVVGKLRKNSRKAK 525
            :...:.|||:|   .:|..::.:||  |:....::....::.||:|
Zfish   482 WYQYHCLDVFAFLTTVLTLVLYICF--KMAKFFIMRCCFRSKRKSK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	149/557 (27%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	141/513 (27%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	146/548 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910