DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	556	Identity:	156/556 - (28%)
Similarity:	253/556 - (45%)	Gaps:	73/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHI 71
            |....:.|..||..| |||...|  ..||.:....:...|.:|||||||        |..|....
Zfish     6 CFLSLLTVFSAGQCG-NILVWHT--EGSHWINLKIVLDTLLDRGHNVTV--------LMPDGALF 59

  Fly    72 LVPMEED--ILQAFNSVVGGMTKTD--NSNAYVSMFR----SVRQLSETFSKMGD---------- 118
            :...|.|  ..|.|:.........|  :...:.|:|.    ::.|:...|..:|.
Zfish    60 MKAKESDRFSYQNFSVSTSAQDMQDFLDELLHFSVFEMEQLNLLQIQMKFFDLGSRHQDMGLSYC 124

  Fly   119 --VMKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLVVAL-----SNPPSFLGYLLG 176
              ::|.|.:.|..:  ..|||:::......|..: :|..|.||||..|     .......|.:..
Zfish   125 DGILKSPELMDKLK--TGKFDVLLSDPMYPCSDI-VAEVLNVPLVFTLRFSIAHTMERICGQIPA 186

  Fly   177 NPWEVSYVPG-MSVSIKGGKPLGFGHRVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSY 240
            .|   ||||| ||   |....:.|..|:.|.|..::...|..|...:....|.|.:| .||  ||
Zfish   187 PP---SYVPGAMS---KLTDKMSFTERIFNTLFYLSMDTFSIIAWKKFDNYYTEYFG-RPT--SY 242

  Fly   241 EDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPER-LPQNMEQFL-SEAPNGAILLS 303
            .::.....:....::...|.| ||.||....|||:..  .|.: ||::||:|: |...:|.::.:
Zfish   243 CEMMGRADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC--TPAKPLPKDMEEFVQSSGDDGIVVFT 304

  Fly   304 LGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGE-----SENILYSKWVPQVDVLAH 363
            |||.:  |.:......::.:.|:::.|||:|::.      ||     .||....||:||.|:|.|
Zfish   305 LGSMI--DKVPKEMSNRIASALAQIPQKVLWRYG------GEKPDTLGENTRIYKWMPQNDLLGH 361

  Fly   364 PNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFG-IKQSILTLEEDSFLQGI 427
            |....||||.|..|:.||.|||.||:.:|:|||||.|...|...|.. :..||.:::....:..:
Zfish   362 PKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKL 426

  Fly   428 REVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVY 492
            ..|:::|.|.......|.::.|||:.|.:..::|:|:|:|..||.|::....::::...:.|||:
Zfish   427 NTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVF 491

  Fly   493 A---VILGTIVALCFITKLLFGLVVGKLRKNSRKAK 525
            |   .:|..::.:||  |:....::....::.||:|
Zfish   492 AFLTTVLTLVLYICF--KMAKFFIMRCCFRSKRKSK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	152/547 (28%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	144/503 (29%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	149/538 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840