DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37B1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	585	Identity:	153/585 - (26%)
Similarity:	262/585 - (44%)	Gaps:	124/585 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QIVVLIA---GAHGANILG--LFTSLSPSHLVIQMSMARILAERGHNVTVVTILKP--------- 61
            ||.||:|   .....::.|  |...:..||.:....:.:.|.:|||.:|||.....
Zfish    64 QISVLVAFIWSLPSLSLAGKILVYPVDGSHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATH 128

  Fly    62 -PSLHKDINHILVPMEE------------DILQAFNSVVGGMTKTDNSNAYVSMFRS-VRQLSET 112
             .|:...:|| |..:|:            ||.:...|:.          :::::.:. :..|.|:
Zfish   129 YTSITIQVNH-LSSLEDPKYMASFLKRNIDIQRGKGSIW----------SFLALQKEIITLLEES 182

  Fly   113 FSKMGDVMK-----QPLVKDLYEHPDNKFDLVMV------GYFMNCYQLALAHKLKVPLVVALSN 166
            .....::::     :.|:|.|.|   :|:||::.      |..:..|       |.:|:|..:..
Zfish   183 HRSTAEMVRVVLEDEKLIKTLKE---SKYDLMLTDPGFAGGVILGAY-------LGLPMVFNVRW 237

  Fly   167 PPSFLGYLLGNPWEVSYVP--GMSVSIKGGKPLGFGHRVLNLL---------GSMAQRLFMFIIE 220
            ..:..|:....|..:||:|  |..|:.|    :.|.:::.|::         ..:.:.|:..:|.
Zfish   238 ITNAEGHFAIAPSPLSYIPTIGSRVTDK----MSFANKLKNIMHFGIGQYIDHMLTRPLYQGVIS 298

  Fly   221 L---RNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPE 282
            .   .|..:|..|.|.|..|       ..:..:|       |.| ||.:|.|:.|||.|.|  |.
Zfish   299 KYIDPNTNVYALIQGADLWL-------MRVDFVF-------EFP-RPTMPNVVYIGGFQCK--PS 346

  Fly   283 R-LPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVL----SKLQQKVIWKWDDLDN 341
            : ||..:.:|: |...:|.:::|||:      |..|.|..:..::    ::|.|||||:.
Zfish   347 KPLPDELNKFVESSGEHGVVIMSLGT------LLGSLVPDISEIVASAFAQLPQKVIWRH----- 400

  Fly   342 IPGE-----SENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNA 401
             .||     ..|.|...|:||.|:|.||....|:||.|..|:.||.|||.|||.||:..||..|.
Zfish   401 -VGEKPSTLGNNTLVVDWLPQNDLLGHPKTKAFVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNI 464

  Fly   402 DVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPK-YATAVKSFSTLYRDRPLSPRETLIYWVEYV 465
            ..:...|......:.||:.|...|.::::||..: |...::..|:|:||.||.|.::.|:|:|:|
Zfish   465 IRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFV 529

  Fly   466 IRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLLFGLVV-GKLRKNSRKAKVNQK 529
            :|:.||.|:::....:.:.:.:.|||.|:|:    :||....||..|:. ..||...||.|..::
Zfish   530 MRHKGAAHLRTESYKLPWYSYHCLDVLALIM----SLCTAAGLLLILISRALLRACVRKIKAKKE 590

Fly 530 529
Zfish 591 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	149/576 (26%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	136/534 (25%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	147/561 (26%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	82/247 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840