DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	523	Identity:	157/523 - (30%)
Similarity:	251/523 - (47%)	Gaps:	77/523 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KALAEAGHNVTV-VSMMQPKVMHK-----DIHLIVVPVTKE--------------------QERT 43
            :||.:..|:||| |....|.|.|.     :.|:..|.:.||                    .|:|
Zfish    41 EALVDKNHSVTVLVGSSSPTVPHTQKERFEYHVFKVNMEKEVVDYLWIHFHELWMNETISTYEKT 105

  Fly    44 LEN-QMASM--AGSKNNIITTMYLLLNGL-DVMVTSQADLLKDPRFQRVFETKFDLMILGSFFND 104
            ||. |:.|:  |.|:.        |:.|| ||      .|||..|     ::.:|::     |:|
Zfish   106 LEVWQLMSLFRAHSEE--------LVKGLFDV------GLLKTLR-----DSNYDVL-----FSD 146

  Fly   105 FQLG----VAGKLKVPVIVDWMIPSNTMIDEFVAN-PSEVSYVPN--ESTFATTPMSFFKRAENL 162
            ..:.    :|.||.:|.::...|...:.::..... |...||||.  .....|..|||.:|.||:
Zfish   147 LTMPFSDLMAQKLNIPHVLSMRISFASALERLCGQMPVPQSYVPAAVAQGHLTDRMSFTERVENM 211

  Fly   163 ---VKHVILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAI 224
               :.|..:..||.:|.  |:.||.||  ..:..|:.|......:..:.::...:.| ||..|..
Zfish   212 LLYITHTAMFQLTTKFT--FDHIYAEI--SGEPTTMCETIGKTDIWLIRTYWDFEYP-RPFPPNF 271

  Fly   225 IEVGGIQVKEQPDPLPQDIEQFMENS-SQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVI 288
            ..|||:|.| ...||.:::|:|:::| ..|.:..|.||.||:..|:.  ...:...|..:.|.|:
Zfish   272 KFVGGLQCK-PAKPLAKELEEFVQSSGDHGIVVFSLGSMIKNLTVQK--ANTIAAALGQISQKVV 333

  Fly   289 WKWEDLENTPGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDH 352
            |::..  .||.. |.|....||:||:|:|.||.||.|:||.|...:.|:.|||||||.||:|||.
Zfish   334 WRYSG--KTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQ 396

  Fly   353 PLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWV 417
            |.|...:.:.|..|.||..|:......:|:..||.|..|.:::.:.|.::.|:|:.|....::|:
Zfish   397 PDNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWI 461

  Fly   418 DYVLRHHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARK 482
            ::|:|:.||.:|:..|..:.:.:.|.||:.|.:|:|...:.||......|||.:.:.|.: |.||
Zfish   462 EFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTR-PERK 525

  Fly   483 KKQ 485
            .|:
Zfish   526 SKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	153/513 (30%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	140/468 (30%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	152/511 (30%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	79/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930