DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	528	Identity:	149/528 - (28%)
Similarity:	249/528 - (47%)	Gaps:	106/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVV----------------------SMMQPKVMHKDI-HLIVVPVTKEQERTLENQM 48
            |...||::|||                      .:.....|.|.: ||:.:   :.|.::..|:|
Zfish    44 LHSRGHSITVVRGSSSWYIEEQSPLYTSITVDNGVFDDDFMEKFLPHLLKI---QRQGKSFWNEM 105

  Fly    49 ASMAGSKNNIIT-------TMYLLLNGLDVMVTSQAD-----LLKDPRFQRVFETKFDLMILGSF 101
            | :|....:.:|       .|..:|...:.::.|..|     :|.||.:             ||
Zfish   106 A-LADEMIHFVTETHKQSCNMTAILFENETLMNSLKDAAYDVVLTDPAY-------------GS- 155

  Fly   102 FNDFQLGV--AGKLKVPVI--VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENL 162
                  ||  |.:|.:|::  |.|.:......|  :| ||.:||||......|..|:|.:|..|:
Zfish   156 ------GVLLAHRLGLPLVYNVRWTVYGEAHFD--IA-PSPLSYVPVSGLQLTDKMTFSQRVMNM 211

  Fly   163 VKHVILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPI---------- 217
            :.:::::|   :::..|...|.|:       |......|::..    .|:.|..:
Zfish   212 MTYIMIRY---KYSKNFGSPYQEL-------TQKYFGPNVNFF----SLLQDADLWLMRNDFTFE 262

  Fly   218 --RPLVPAIIEVGGIQVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYM--VKPEIVGIMF 277
              ||.:|.::.:||.|.| ...|||.|:|:|:::|.: |.|.:|.|:.....:  :..||..
Zfish   263 FPRPTMPNVVYMGGFQCK-PAKPLPGDLEEFVQSSGEHGVIMMSLGTVFGQLLSELNDEIAA--- 323

  Fly   278 KVLSGLKQNVIWKWEDLENTPGN-ASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGV 341
             ..:.|.|.|||::..  ..|.| .:|....:||||:|:|.||.|||||.|.|...:.|:.||||
Zfish   324 -AFAQLPQKVIWRYTG--PRPANLGNNTLIVNWLPQNDLLGHPKTKLFVAHGGTNGLQEAIYHGV 385

  Fly   342 PMVALPIFGDHPLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRP 406
            |:|.||:..|.|.|.:.|...|....::..|:....|.||:.|||.|..|.:.:::.|.|:.|:|
Zfish   386 PIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFLEALKEVLHNPSYRENMQRLSKLHHDQP 450

  Fly   407 LTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVELHNLD-IYALVLAILIFLVFLTRLTVKFLFS 470
            :.|....:||:::|:|:.|||:|::.:..|.::|..::| |..|:|.:|:| |.||..|:|: |.
Zfish   451 MKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDVILTLMLMVLVF-VLLTVYTMKY-FC 513

  Fly   471 KLLGKAKV 478
            ..|.:.||
Zfish   514 LCLFRKKV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	147/525 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	132/480 (28%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	149/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584457
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740