DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	509	Identity:	144/509 - (28%)
Similarity:	242/509 - (47%)	Gaps:	86/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVVSMMQPKVMHKD---IHLIVVPVT----KEQERTLENQMASMAGSKNNIITTMYL 64
            |...|||||||.......:.::   ...|.:|.|    :|....|.|::..:....       |.
Zfish    44 LHRKGHNVTVVRPSNSWYIKEESPFYSSITIPNTGGFDEEFSGLLINRLLEIKRGG-------YF 101

  Fly    65 LLNGL----DVMV---TSQADLLK--------DPRFQRVFETKFDLMILGSFFNDFQLG----VA 110
            :||.:    ::|:   |...|:|:        :.....:.:.|||:::.     |..:|    :|
Zfish   102 VLNRVRLEFEIMMKFKTMHEDMLQMMDRMLEDEKVMNSIQDAKFDVVLA-----DPAVGGGPILA 161

  Fly   111 GKLKVPVI--VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVI------ 167
            .|..:|::  |.|.|...   ..|...||.:||:|......|..|||.:|.:|::.::|
Zfish   162 YKFNIPLVFNVRWTIQGE---GHFAIAPSPLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQ 223

  Fly   168 --LKYLTIRFNYKF---NRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEV 227
              ::.:...|.:|.   |..|..:|.|.|   :..|:.:.:..|.          ||.:|.|:.:
Zfish   224 IMVEPIYAPFCHKHFGPNVTYFSLFQDAD---IWLMRNDFTFEFP----------RPTMPNIVYM 275

  Fly   228 GGIQVKEQPDPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKW 291
            .|.|.| ...|||.|:|:|:|:|.: |.|.:|.|:.|.  .:..::...:....:.|.|.|||::
Zfish   276 SGFQCK-PAKPLPNDLEKFVESSGEHGVIVMSLGTLIA--QLPQDMTDDIAAAFAELPQKVIWRY 337

  Fly   292 EDLEN-TPGNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLN 355
            ..... |.||  |....:||||:|:|.||..|:||.|.|...|.|:.|||||::.||:..|.|.|
Zfish   338 TGPRPVTLGN--NTLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDN 400

  Fly   356 AALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYV 420
            ...|...|....:|:.|:.:..|.||:.|||.|..|.:.:::.|.|:.|:||.|....:||:::|
Zfish   401 LFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFV 465

  Fly   421 LRHHGAPNLQSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLG 474
            :|:.|||:|::.:..|.::|.|::|            |.||.:...|:|:.::|
Zfish   466 MRNKGAPHLRTQSFRMSWIEYHSID------------VILTLMVTGFVFALMIG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	144/509 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	134/466 (29%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	144/509 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740