DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and Ugt305A1

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	129/558 - (23%)
Similarity:	228/558 - (40%)	Gaps:	125/558 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTAK------------ALAEAGHNVTVVSMM---QPK----------------VMHKDIHLIVV 34
            :||||            ||...||::.|:|..   :||                ||.:  |.::
  Fly    28 VSTAKHNNPGWSKPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHLPNEYDVMKR--HFLL- 89

  Fly    35 PVTKEQERTLENQMASMAGSKNNIITTMYLLLNGLDVMVTSQADLLKDPRFQRVFETKFDLMILG 99
                |:.|    :..||. :.|.::....:||.....::.|.....|.|........::||:|
  Fly    90 ----EEPR----EYISMV-TLNQLLVWYEVLLGSCRALLNSDTMSSKRPELTAQLSMEYDLII-- 143

  Fly   100 SFFNDFQLGV-------------------AGKLKVPVIVDWMIPSNTMIDEFVANPSEVSYVPNE 145
               .|...|:                   |||| .|.::..:...||:  .....|..:|.||.
  Fly   144 ---TDVTQGIECLMDSVSGWRSKPVLGLSAGKL-TPDLMSLLRAENTI--NAARIPHYISQVPK- 201

  Fly   146 STFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRIYNEIFTDKDMPTLSEMKK------NISM 204
                  .|.|:.|..|   |::         |....:.:.:.|   .|.|||:.|      .:.:
  Fly   202 ------TMGFWNRLHN---HIM---------YYAEPLIHLVIT---RPVLSELMKTENAFPKLQL 245

  Fly   205 VFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFMENSSQGAIFLSFGSNIKSYMVK 269
            |.:.:|...| .::.|.|.:|||||:.:|.|..|||..|::|.|....|.::::.     .|:..
  Fly   246 VLLNTHPTLD-YVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGIVYINM-----PYIEY 304

  Fly   270 PEIVGI--MFKVLSGLKQNV--IWKWEDLENTPGNASNI--FYKDWLPQDDILAHPNTKLFVTHA 328
            ....|:  |:.::.| ..||  ||..|.||..|....|:  .:.:...|.||||....|.|:.|.
  Fly   305 MNDQGLKAMYTMIHG-NPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSLQQDILAMQYVKGFLNHG 368

  Fly   329 GKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITEDTFREAINEVLENDKYTQ 393
            ...|:.|:.::|||:|.||:..:...||..::....||.|.::...:.:..:|:..:|:.:::..
  Fly   369 DSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDALTRILDEERFIS 433

  Fly   394 AVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNL-----QSPAVHMGFVELHNLDIYALVLAI 453
            |:.:....:|.||.:..:..::..:.::   ..|.|     |:..:...|...::||:..:.|.:
  Fly   434 ALHQAQLKFRTRPQSALELAVWHAEQLI---AEPRLFKHFAQTETLAQNFFVANSLDVLTVPLIV 495

  Fly   454 LIFLVFLTRLTVKFLFS------KLLGKAKVPARKKKQ 485
            |:..|......|..|::      :.|.||.:..|||.:
  Fly   496 LLAAVVSLANLVYVLYTGGSKRQQTLEKAVLKKRKKSK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	125/548 (23%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	111/481 (23%)
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	59/225 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445822
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950