DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	500	Identity:	137/500 - (27%)
Similarity:	252/500 - (50%)	Gaps:	36/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTVVSMMQPKVMHKD----IHLIVVPVTKEQ---ERTLENQMASMAGSKNNIIT--TM 62
            |.:..|||||::......::.:    ::..|:||:.::   :..:|:.:......:...:|  ..
Human    52 LIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAF 116

  Fly    63 Y-----LLLNGLDVMVTSQADLLKDPRFQ-RVFETKFDLMILG--SFFNDFQLGVAGKLKVPVIV 119
            |     ||.....:.:.....:||:|:.. |:.:..||:::..  :...|.   ||.||.:|.:.
Human   117 YKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTICGDL---VALKLGIPFMY 178

  Fly   120 DWMI-PSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRIY 183
            .... |::|:.......|:.|||||...:..|..|:|.:|.:|.:.:.:..|:...:..::|..|
Human   179 TLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYY 243

  Fly   184 NEIFTDKDMP-TLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQFM 247
            ::|.   ..| ||.|......:..:.::...:.| ||.:|....|||:..| ...|||:::|:|:
Human   244 SKIL---GRPTTLCETMGKAEIWLIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFI 303

  Fly   248 ENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLE-NTPGNASNIFYKDWL 310
            ::|.: |.:..|.||.:|:  :..|...::...|:.:.|.|:|:::..: .|.||.:.:|  ||:
Human   304 QSSGKNGVVVFSLGSMVKN--LTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWI 364

  Fly   311 PQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITE 375
            ||:|:|.||.||.|:||.|...|.|:.|||||||.:|:|.|.|.|.|.|...|..|.::|.|:|.
Human   365 PQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS 429

  Fly   376 DTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVE 440
            .....|:..|:....|.:...:.|.::.|:|:.|....:||:::|:||.||.:|:..|..:.:.:
Human   430 VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQ 494

  Fly   441 LHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKKQ 485
            .|:||:...:|..:...:||......|...|.   .|:..:||::
Human   495 YHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKF---GKIGKKKKRE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	134/490 (27%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	125/446 (28%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	133/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740