DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	510	Identity:	142/510 - (27%)
Similarity:	247/510 - (48%)	Gaps:	58/510 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KALAEAGHNVTVV---SMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMA----GSKNNIITTM 62
            |||...||::.|:   :....|......:.|.:|.:|..:....:.|.|..    ..|::.::|:
Zfish    48 KALHGKGHSIDVIRNTNSWYVKEKSDYYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTV 112

  Fly    63 YLLLNG-------------LDVMVTSQADLLKDPRFQRVFETKFDLMILGSFFNDFQLGV--AGK 112
            .|..:.             :...:....::||     .:.|.::|||:....:.   :|:  |.|
Zfish   113 KLFFDSVIDNYEMTKMVCDITTSIFESEEILK-----TLQEKQYDLMLTDPVWG---MGIILAHK 169

  Fly   113 LKVPVI--VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRF 175
            ||:|::  |.|   :.|:...|...||.:||:|...:..|..||||:|.:|     |:.|.|...
Zfish   170 LKLPMVYNVRW---TTTVDGHFNIAPSPMSYIPITGSGNTDRMSFFQRVKN-----IIFYFTNDI 226

  Fly   176 NY-KFNRIYNEIFTDK--DMPT-LSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQP 236
            .| :|:....:...||  |.|. ..::.:...:..:....:.:.| ||.:|.||..||.|. ...
Zfish   227 KYSRFSLPQYQAICDKYFDPPVDFYQLLQGADIWLMRVDFVFEFP-RPTMPNIIYTGGFQC-TPA 289

  Fly   237 DPLPQDIEQFMENS-SQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLE-NTPG 299
            .|||.|:|.||::| ..|.|.:|.|:.|.:  :..::...:....:.|.|.|||::...: :|.|
Zfish   290 KPLPHDLEDFMQSSGDHGVIVMSLGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLG 352

  Fly   300 NASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGY 364
            |  |....||:||.|:|.||.||:||.|.|...:.|:.|||||:|.:|.|.|...|...:...|.
Zfish   353 N--NTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGG 415

  Fly   365 GVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNL 429
            ...:.|..:.|::...||.||:.|..|...::|.|.|:.|:|:.|..|.:||:::|:||.||.:|
Zfish   416 AKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHL 480

  Fly   430 QSPAVHMGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKK 484
            ::.:..|.:...|::|:...::|:::..:|.....|:::..|..      :||:|
Zfish   481 RTESYKMPWYSYHSVDVAVTLIAVVLIFIFSIFYVVRYVCIKCC------SRKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	139/501 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	131/456 (29%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	142/510 (28%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	84/245 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740