DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	505	Identity:	140/505 - (27%)
Similarity:	242/505 - (47%)	Gaps:	45/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAEAGHNVTV-VSMMQPKV----MHKDIHLIV-VPVTKEQERTLENQMA---SMAGSKNNIITTM 62
            |....|.||| |....|.:    ..:..:|:. ||::.::......::.   :...|.|.:.|.:
Zfish    45 LLNRNHTVTVLVCSASPTINFTQQERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTAL 109

  Fly    63 YL--LLNGLDVMVTSQAD--LLKDPRFQRVFETKFDLMILGSFFND--FQLG--VAGKLKVPVIV 119
            .:  ||..:.||..:..|  |..|....::...|||::     |||  |...  :|..|.:|:::
Zfish   110 QIIELLGRVRVMHRAMCDSMLRNDALIAQLSALKFDVL-----FNDPMFMCADLLAEMLGLPLVL 169

  Fly   120 DWMIPSNTMIDEFVAN-PSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRI- 182
            ...|.....::..... |:..|:||...|..|..|.|.:|.:|::.:::       |:..|..:
Zfish   170 SVRISPGFCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIV-------FSVSFYIVA 227

  Fly   183 ---YNEIFTD--KDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQD 242
               .:..:||  ....|:.|......:..:.::...:.| ||..|....|||:..| ...||.::
Zfish   228 WISLDSYYTDVLGKPTTMCETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKE 290

  Fly   243 IEQFMENS-SQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGN-ASNIF 305
            :|:|:::| ..|.:..|.||.||:  :..|....:...|..:.|.|:|::..  .||.. |.|..
Zfish   291 MEEFVQSSGDHGVVVFSLGSMIKN--LTSERANTIAAALGQIPQKVVWRYSG--KTPETLAPNTK 351

  Fly   306 YKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDL 370
            ..||:||:|:|.||.||.|:||.|...:.|:.|||||||.||:|.|.|.|...|...|..|.||:
Zfish   352 IYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDI 416

  Fly   371 QTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVH 435
            .|:......:|:..||.|..|.:::.:.|.::.|:|:.|....::|:::|:|:.||.:|:..|..
Zfish   417 NTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHE 481

  Fly   436 MGFVELHNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKKQ 485
            :.:.:.|.||:.|.:|:|...:.||......|||.:.:.|.: |.||.::
Zfish   482 LSWYQYHCLDVAAFLLSIAALITFLWVKACCFLFRRCVRKTR-PERKTQK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	137/495 (28%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	124/451 (27%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	136/493 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	78/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810